The increased effective connectivity from left middle occipital gyrus to right medial septum/diagonal bands in AD patients after donepezil intervention.
Introduction: Donepezil enhances the function of cholinergic nerves by increasing the concentration of acetylcholine, thereby improving clinical symptoms in patients with Alzheimer’s disease (AD). However, the neural mechanisms of how donepezil modulates the effective connectivity (EC) network of ch...
| Published in: | Frontiers in Aging Neuroscience pp. 1 - 9 |
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| Main Authors: | , , , , , , |
| Format: | diagnostic images research tables/charts Journal Article |
| Published: |
Frontiers Media S.A.
2024
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| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=176955525&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 176955525 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 16634365 BG2U jtl: Frontiers in Aging Neuroscience issn: 16634365 maglogo: N pubinfo: dt: 2024 pid: 40038 pub: Frontiers Media S.A. artinfo: ui: 176955525 176955525 176955525 10.3389/fnagi.2024.1362790 176955525 ppf: 1 ppct: 8 formats: tig: atl: The increased effective connectivity from left middle occipital gyrus to right medial septum/diagonal bands in AD patients after donepezil intervention. aug: au: Ting Yang Fuquan Wei Yufei Guo Mengxiao Zhu Hongtao Hou Zhongwei Guo Xiaozheng Liu affil: The Second Affiliated Hospital and Yuying Children’s Hospital, Wenzhou Medical University, Wenzhou, Zhejiang, China. sug: subj: Alzheimer's Disease Drug Therapy Donepezil Therapeutic Use Brain Mapping Methods Occipital Lobe Radiography Telencephalon Radiography Neural Pathways Acetylcholine Therapeutic Use Treatment Outcomes Human Male Female Middle Age Aged Hospitals Prospective Studies Cross Sectional Studies Neuropsychological Tests Psychological Tests Questionnaires Cognition Magnetic Resonance Imaging Methods Brain Physiology Default Mode Network Prefrontal Cortex Cholinergic Agents Risk Assessment Descriptive Statistics Comparative Studies Analysis of Variance Post Hoc Analysis T-Tests Data Analysis Software Chi Square Test Funding Source Middle Aged: 45-64 years Aged: 65+ years Male Female ab: Introduction: Donepezil enhances the function of cholinergic nerves by increasing the concentration of acetylcholine, thereby improving clinical symptoms in patients with Alzheimer’s disease (AD). However, the neural mechanisms of how donepezil modulates the effective connectivity (EC) network of cholinergic system in AD patients remain unknown. We speculated that the effective network of the cholinergic system changes in AD patients after donepezil intervention. Methods: We employed resting-state functional magnetic resonance imaging and Granger causality analysis approach to explore changes in the effective connectivity network of the basal forebrain in AD patients before and after donepezil intervention. This study included 32 participants, including 16 healthy controls (HCs) and 16 AD patients. In a 3T MRI scanner, the 16 AD patients were scanned before and after the donepezil intervention. To compare EC differences between the three groups of participants, ANOVA and post-hoc t-tests analysis were employed. Results: Compared to baseline status, AD patients after donepezil intervention had an increased EC from left middle occipital gyrus to right medial septum/diagonal bands. Compared to HCs, AD patients after donepezil intervention had an increased EC from right inferior frontal gyrus/orbit part to right medial septum/diagonal bands, AD patients before donepezil intervention had a reduced EC from right precuneus to right medial septum/diagonal bands. A significant positive correlation was found between EC values in right precuneus and Mini-Mental State Examination in pre-intervention AD patients (r = 0.7338, p = 0.0012). Discussion: Our study showed that effective connectivity of brain regions associated with the default mode network in the cholinergic pathway was enhanced after donepezil intervention. The results of this study will help us to better understand the neural mechanisms of donepezil intervention in AD and to find clinical targets for intervention. pubtype: Academic Journal doctype: diagnostic images research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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