Characterization and Classification of ADHD Subtypes: An Approach Based on the Nodal Distribution of Eigenvector Centrality and Classification Tree Model.

In recent times, the complex network theory is increasingly applied to characterize, classify, and diagnose a broad spectrum of neuropathological conditions, including attention deficit hyperactivity disorder (ADHD), Alzheimer's disease, bipolar disorder, and many others. Nevertheless, the diagnosis...

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Publicado en:Child Psychiatry & Human Development Vol. 55; no. 3; pp. 622 - 635
Autores principales: Saha, Papri, Sarkar, Debasish
Formato: Artículo
Publicado: Springer Nature Jun2024
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Acceso en línea:Ver este registro en EBSCOhost
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      dt: Jun2024
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      pub: Springer Nature
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        10.1007/s10578-022-01432-6
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        atl: Characterization and Classification of ADHD Subtypes: An Approach Based on the Nodal Distribution of Eigenvector Centrality and Classification Tree Model.
      aug:
        au:
          Saha, Papri
          Sarkar, Debasish
        affil:
          Department of Computer Science, Derozio Memorial College, 700136, Kolkata, India
          https://ror.org/01e7v7w47 Department of Chemical Engineering, University of Calcutta, 700009, Kolkata, India
      su:
        Attention-deficit hyperactivity disorder
        Alzheimer's disease
        Functional magnetic resonance imaging
      sug:
        subj:
          Attention-deficit hyperactivity disorder
          Alzheimer's disease
          Functional magnetic resonance imaging
      keyword:
        Brain networks
        Correlation matrix
        Functional connectivity
        Machine learning
        Region of interest
        Brain networks
        Correlation matrix
        Functional connectivity
        Machine learning
        Region of interest
      ab: In recent times, the complex network theory is increasingly applied to characterize, classify, and diagnose a broad spectrum of neuropathological conditions, including attention deficit hyperactivity disorder (ADHD), Alzheimer's disease, bipolar disorder, and many others. Nevertheless, the diagnosis and associated subtype identification majorly rely on the baseline correlation matrix obtained from the functional MRI scan. Thus, the existing protocols are either full of personalized bias or computationally expensive as network complexity-based simple but deterministic protocols are yet to be developed and formalized. This article proposes a deterministic method to identify and differentiate the common ADHD subtypes, which is based on a single complexity measure, namely the eigenvector centrality. The node-wise centrality differences were explored using a classification tree model (p < 0.05) to diagnose the subtypes. Identification of marker nodes from default mode, visual, frontoparietal, limbic, and cerebellar networks strongly vouch for the involvement of multiple brain regions in ADHD neuropathology.
      pubtype: Academic Journal
      doctype: Article
      src: R
    language: English
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