Effect of intra-abdominal boric acid in the experimental adhesion model.
BACKGROUND: The continuous advancement in medical and surgical techniques has led to a rise in the frequency of abdominal operations, subsequently increasing the incidence of intra-abdominal adhesions. Over 90% of laparotomies result in postoperative intra-abdominal adhesions. This study investigate...
| Publicado en: | Turkish Journal of Trauma & Emergency Surgery / Ulusal Travma ve Acil Cerrahi Dergisi Vol. 30; no. 4; pp. 236 - 242 |
|---|---|
| Autores principales: | , , |
| Formato: | pictorial research tables/charts Journal Article |
| Publicado: |
KARE Publishing
Apr2024
|
| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=177023234&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 177023234 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 1306696X 84TB jtl: Turkish Journal of Trauma & Emergency Surgery / Ulusal Travma ve Acil Cerrahi Dergisi issn: 1306696X maglogo: N pubinfo: dt: Apr2024 vid: 30 iid: 4 pid: 62027 pub: KARE Publishing artinfo: ui: 177023234 177023234 177023234 10.14744/tjtes.2024.77767 177023234 ppf: 236 ppct: 6 formats: tig: atl: Effect of intra-abdominal boric acid in the experimental adhesion model. aug: au: Kabalar, Rıdvan Barkın Şahin, Semra Tutcu Ayhan, Semin affil: Department of General Surgery, Izmir Bergama Necla-Mithat Ozture State Hospital, İzmir-Türkiye sug: subj: Abdomen Surgery Boric Acids Therapeutic Use Boric Acids Administration and Dosage Adhesions Prevention and Control Postoperative Complications Prevention and Control Drug Efficacy Evaluation Administration, Intraperitoneal Animal Studies Rats Experimental Studies Comparative Studies Microscopy Methods Mann-Whitney U Test Data Analysis Software Models, Biological Funding Source ab: BACKGROUND: The continuous advancement in medical and surgical techniques has led to a rise in the frequency of abdominal operations, subsequently increasing the incidence of intra-abdominal adhesions. Over 90% of laparotomies result in postoperative intra-abdominal adhesions. This study investigates the effect of a 5% boric acid solution on the development of intra-abdominal adhesions in rats, using an adhesion model. METHODS: This study was conducted with two groups: a control group, in which the adhesion model was applied without any treatment, and a boric acid group, which was treated with a 5% boric acid solution. Each group comprised 16 rats. On the 14th postoperative day, the rats were sacrificed, re-explored, and the developed adhesions were evaluated both macroscopically and microscopically. The data from macroscopic and microscopic scoring were analyzed using the Mann-Whitney U test in the IBM Statistical Package for the Social Sciences (SPSS) Statistics 24 program. A p-value of less than 0.05 was considered statistically significant. This research was supported by the Manisa Celal Bayar University Scientific Research Projects Commission. RESULTS: A statistically significant difference was observed between the boric acid-treated group and the control group, with the boric acid group showing a significant decrease in adhesion development both macroscopically and microscopically (p<0.05). CONCLUSION: In the future, boron could play a significant role in reducing and preventing intra-abdominal adhesions after surgery. This investigation could pave the way for further research into the mechanism by which boric acid prevents the development of intra-abdominal adhesions. Moreover, it is imperative to explore the potential side effects of intra-abdominal boron application at the optimum concentration of the solution. AMAÇ: Bu çalışmada; batın cerrahilerinin giderek daha fazla sayıda yapılmasıyla sıklıkla karşılaşılan ve ciddi mortalite ile morbidite sebebi olan intraabdominal adezyonların azaltılabilmesi için; adezyon modeli oluşturulmuş ratlarda, %5 borik asit solüsyonu uygulamasının batın içi adezyon gelişimine etkisini araştırmak amaçlanmıştır. Borik asidin daha önce kanıtlanmış olan antiinflamatuvar, antioksidan ve antifibrotik etkileri ile intraabdominal adezyon gelişimini azaltacağı düşünülmüştür. GEREÇ VE YÖNTEM: Çalışma her biri 16 adet rat içeren 2 grupta (adezyon modeli oluşturulmuş kontrol grubu ve %5'lik borik asit solüsyonu uygulanmış deney grubu) yapıldı. Operasyon sonrası 14. günde ratlar sakrifiye edilip tekrar eksplore edildi ve gelişen adezyonlar makroskopik ve mikroskopik olarak değerlendirildi. Makroskopik ve mikroskobik skorlamalar sonucunda elde edilen veriler IBM SPSS Statistics 24 programında Mann-Whitney U testi ile değerlendirildi. İstatistiksel anlamlılık düzeyi "p<0.05" olarak belirlendi. BULGULAR: İstatistiksel veriler incelendiğinde borik asit uygulanan grupta adezyon gelişiminde makroskopik ve mikroskopik olarak anlamlı bir azalma olduğu görüldü (p<0.05). SONUÇ: Bu çalışmanın sonucunda; deneysel adezyon modelinde intraabdominal %5' lik borik asit solüsyonu uygulamasının, postoperatif intraabdominal adezyonları azaltmada anlamlı etkiye sahip olabileceği gösterilmiştir. Bu etkinin borik asidin antiinflamatuvar, antioksidan ve antifibrotik etkilerinden kaynaklandığı öngörülmektedir. Bu çalışma, borik asidin intraabdominal adezyonları azaltma mekanizmasının ve ideal dozun araştırılması için öncü olacaktır. pubtype: Academic Journal doctype: pictorial research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
|---|