Autoimmune, Autoinflammatory Disease and Cutaneous Malignancy Associations with Hidradenitis Suppurativa: A Cross-Sectional Study.
Background: Hidradenitis suppurativa (HS) is a debilitating cutaneous disease characterized by severe painful inflammatory nodules/abscesses. At present, data regarding the epidemiology and pathophysiology of this disease are limited. Objective: To define the prevalence and comorbidity associations...
| Publicado en: | American Journal of Clinical Dermatology Vol. 25; no. 3; pp. 473 - 485 |
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| Autores principales: | , , , , , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Springer Nature
May2024
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=177044029&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 177044029 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 11750561 C4Q jtl: American Journal of Clinical Dermatology issn: 11750561 maglogo: N pubinfo: dt: May2024 vid: 25 iid: 3 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 177044029 175322882 177044029 177044029 10.1007/s40257-024-00844-5 177044029 ppf: 473 ppct: 12 formats: tig: atl: Autoimmune, Autoinflammatory Disease and Cutaneous Malignancy Associations with Hidradenitis Suppurativa: A Cross-Sectional Study. aug: au: Brydges, Hilliard T. Onuh, Ogechukwu C. Friedman, Rebecca Barrett, Joy Betensky, Rebecca A. Lu, Catherine P. Caplan, Avrom S. Alavi, Afsaneh Chiu, Ernest S. affil: https://ror.org/0190ak572 Hansjörg Wyss Department of Plastic Surgery, New York University Langone Health, 240 E 38th Street, 13th Floor, 10016, New York, NY, USA sug: subj: Hidradenitis Suppurativa Epidemiology Hidradenitis Suppurativa Complications Autoimmune Diseases Risk Factors Inflammation Risk Factors Skin Diseases Risk Factors Comorbidity Risk Assessment Human United States Cross Sectional Studies Pyoderma Gangrenosum Risk Factors Down Syndrome Risk Factors Polyendocrine Metabolic Ovarian Syndrome Risk Factors Lupus Erythematosus, Systemic Risk Factors Lupus Erythematosus, Cutaneous Risk Factors Multiple Sclerosis Risk Factors Melanoma Risk Factors Carcinoma, Basal Cell Risk Factors Race Factors ab: Background: Hidradenitis suppurativa (HS) is a debilitating cutaneous disease characterized by severe painful inflammatory nodules/abscesses. At present, data regarding the epidemiology and pathophysiology of this disease are limited. Objective: To define the prevalence and comorbidity associations of HS. Methods: This was a cross-sectional study of EPICTM Cosmos© examining over 180 million US patients. Prevalences were calculated by demographic and odds ratios (OR) and identified comorbidity correlations. Results: All examined metabolism-related, psychological, and autoimmune/autoinflammatory (AI) diseases correlated with HS. The strongest associations were with pyoderma gangrenosum [OR 26.56; confidence interval (CI): 24.98–28.23], Down syndrome (OR 11.31; CI 10.93–11.70), and polycystic ovarian syndrome (OR 11.24; CI 11.09–11.38). Novel AI associations were found between HS and lupus (OR 6.60; CI 6.26–6.94) and multiple sclerosis (MS; OR 2.38; CI 2.29–2.48). Cutaneous malignancies were largely not associated in the unsegmented cohort; however, among Black patients, novel associations with melanoma (OR 2.39; CI 1.86–3.08) and basal cell carcinoma (OR 2.69; CI 2.15–3.36) were identified. Limitations: International Classification of Diseases (ICD)-based disease identification relies on coding fidelity and diagnostic accuracy. Conclusion: This is the first study to identify correlations between HS with melanoma and basal cell carcinoma (BCC) among Black patients as well as MS and lupus in all patients with HS. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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