Evaluation of the Diagnostic Utility of Selected Serum Adipokines and Cytokines in Subjects with MASLD—A Pilot Study.
Excess adipose tissue, particularly of the visceral type, triggering chronic low-grade inflammation and altering its secretory profile, is a contributing factor to the initiation and progression of metabolic dysfunction-associated steatotic liver disease (MASLD). This study aimed to compare the leve...
| Publicado en: | Nutrients Vol. 16; no. 9; pp. 1381 - 1398 |
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| Autores principales: | , , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
MDPI
May2024
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=177180021&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 177180021 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 20726643 B0TT jtl: Nutrients issn: 20726643 maglogo: N pubinfo: dt: May2024 vid: 16 iid: 9 pid: 97109 pub: MDPI artinfo: ui: 177180021 177180021 177180021 10.3390/nu16091381 177180021 ppf: 1381 ppct: 17 formats: tig: atl: Evaluation of the Diagnostic Utility of Selected Serum Adipokines and Cytokines in Subjects with MASLD—A Pilot Study. aug: au: Zyśk, Beata Ostrowska, Lucyna Smarkusz-Zarzecka, Joanna Orywal, Karolina Mroczko, Barbara Cwalina, Urszula affil: Department of Dietetics and Clinical Nutrition, Medical University of Bialystok, Mieszka I 4B Street, 15-054 Bialystok, Poland sug: subj: Nonalcoholic Fatty Liver Disease Diagnosis Metabolic Diseases Complications Nonalcoholic Fatty Liver Disease Risk Factors Adipokines Blood Cytokines Blood Adipokines Diagnostic Use Cytokines Diagnostic Use Risk Assessment Obesity Human Female Male Nonexperimental Studies Pilot Studies Adipose Tissue Body Mass Index Body Composition Interleukins Blood Matrix Metalloproteinases Blood Analysis of Variance Multivariate Analysis Regression Kruskal-Wallis Test Data Analysis Software ROC Curve Confidence Intervals Descriptive Statistics Funding Source Female Male ab: Excess adipose tissue, particularly of the visceral type, triggering chronic low-grade inflammation and altering its secretory profile, is a contributing factor to the initiation and progression of metabolic dysfunction-associated steatotic liver disease (MASLD). This study aimed to compare the levels of selected adipokines and cytokines in individuals with normal weight and obesity, assessing their potential for diagnosing MASLD and establishing a cutoff point for body fat content associated with hepatic steatosis development. The research involved 99 participants categorized by body mass index and MASLD presence, undergoing body composition analysis, liver elastography, biochemical tests, and evaluation of adipokines and cytokines in serum. The results indicated elevated IL-6 (interleukin 6) serum levels in individuals with obesity with MASLD compared to the normal-weight group without MASLD. The multivariate regression analysis demonstrated a connection between hepatic steatosis and total adipose tissue content, VAT (visceral adipose tissue), VAT/SAT (subcutaneous adipose tissue) ratio, HOMA-IR (homeostasis model assessment of insulin resistance), IL-6, Il-1β (interleukin 1β), and MMP-2 (matrix metalloproteinase 2). Among the adipokines and cytokines examined in this study, interleukin 6 was the strongest predictor of MASLD regardless of gender. In addition, an association between the development of hepatic steatosis and higher serum IL-1β levels and higher adipose tissue was observed in women. However, further studies on a larger group of patients are needed to consider the use of these cytokines as markers of MASLD. The HOMA-IR index demonstrated potential diagnostic utility in identifying hepatic steatosis. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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