Early features of pancreatic cancer on magnetic resonance imaging (MRI): a case–control study.
Purpose: Magnetic resonance imaging has been recommended as a primary imaging modality among high-risk individuals undergoing screening for pancreatic cancer. We aimed to delineate potential precursor lesions for pancreatic cancer on MR imaging. Methods: We conducted a case–control study at Kaiser P...
| Publicado en: | Abdominal Radiology Vol. 49; no. 5; pp. 1489 - 1502 |
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| Autores principales: | , , , , , |
| Formato: | Journal Article |
| Publicado: |
Springer Nature
May2024
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=177371148&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 177371148 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 2366004X JT14 jtl: Abdominal Radiology issn: 2366004X maglogo: N pubinfo: dt: May2024 vid: 49 iid: 5 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 177371148 176428353 10.1007/s00261-024-04271-2 177371148 ppf: 1489 ppct: 13 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Early features of pancreatic cancer on magnetic resonance imaging (MRI): a case–control study. aug: au: Parker, Rex A. Zhou, Yichen Puttock, Eric J. Chen, Wansu Lustigova, Eva Wu, Bechien U. affil: Department of Radiology, University of Kansas Medical Center, Mail Stop 4032, 3901 Rainbow Blvd., 66160, Kansas City, KS, USA sug: ab: Purpose: Magnetic resonance imaging has been recommended as a primary imaging modality among high-risk individuals undergoing screening for pancreatic cancer. We aimed to delineate potential precursor lesions for pancreatic cancer on MR imaging. Methods: We conducted a case–control study at Kaiser Permanente Southern California (2008–2018) among patients that developed pancreatic cancer who had pre-diagnostic MRI examinations obtained 2–36 months prior to cancer diagnosis (cases) matched 1:2 by age, gender, race/ethnicity, contrast status and year of scan (controls). Patients with history of acute/chronic pancreatitis or prior pancreatic surgery were excluded. Images underwent blind review with assessment of a priori defined series of parenchymal and ductal features. We performed logistic regression to assess the associations between individual factors and pancreatic cancer. We further assessed the interaction among features as well as performed a sensitivity analysis stratifying based on specific time-windows (2–3 months, 4–12 months, 13–36 months prior to cancer diagnosis). Results: We identified 141 cases (37.9% stage I-II, 2.1% III, 31.4% IV, 28.6% unknown) and 292 matched controls. A solid mass was noted in 24 (17%) of the pre-diagnostic MRI scans. Compared to controls, pre-diagnostic images from cancer cases more frequently exhibited the following ductal findings: main duct dilatation (51.4% vs 14.3%, OR [95% CI]: 7.75 [4.19–15.44], focal pancreatic duct stricture with distal (upstream) dilatation (43.6% vs 5.6%, OR 12.71 [6.02–30.89], irregularity (42.1% vs 6.0%, OR 9.73 [4.91–21.43]), focal pancreatic side branch dilation (13.6% vs1.6%, OR 11.57 [3.38–61.32]) as well as parenchymal features: atrophy (57.9% vs 27.4%, OR 46.4 [2.71–8.28], focal area of signal abnormality (39.3% vs 4.8%, OR 15.69 [6.72–44,78]), all p < 0.001). Conclusion: In addition to potential missed lesions, we have identified a series of ductal and parenchymal features on MRI that are associated with increased odds of developing pancreatic cancer. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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