Cerebrovascular Reactivity Following Spinal Cord Injury.
Spinal cord injuries (SCI) often result in cardiovascular issues, increasing the risk of stroke and cognitive deficits. This study assessed cerebrovascular reactivity (CVR) using functional magnetic resonance imaging (fMRI) during a hypercapnic challenge in SCI participants compared to noninjured co...
| Publicado en: | Topics in Spinal Cord Injury Rehabilitation Vol. 30; no. 2; pp. 78 - 96 |
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| Autores principales: | , , , , , , , , , |
| Formato: | diagnostic images pictorial research tables/charts Journal Article |
| Publicado: |
KnowledgeWorks Global, Ltd
Spring2024
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=177423471&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 177423471 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 10820744 0OF jtl: Topics in Spinal Cord Injury Rehabilitation issn: 10820744 maglogo: N pubinfo: dt: Spring2024 vid: 30 iid: 2 pid: 81084 pub: KnowledgeWorks Global, Ltd place: Richmond, Virginia artinfo: ui: 177423471 177423471 177423471 10.46292/sci23-00068 177423471 ppf: 78 ppct: 18 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Cerebrovascular Reactivity Following Spinal Cord Injury. aug: au: Weber, Alexander Mark Nightingale, Tom E. Jarrett, Michael Lee, Amanda H. X. Campbell, Olivia Lauren Walter, Matthias Lucas, Samuel J. E. Phillips, Aaron Rauscher, Alexander Krassioukov, Andrei V. affil: Division of Neurology, Department of Pediatrics, University of British Columbia, Vancouver, BC, Canada sug: subj: Spinal Cord Injuries Complications Cerebrovascular Circulation Evaluation Magnetic Resonance Imaging Methods Hypercapnia Spinal Cord Injuries Physiopathology Human Male Female Adult Middle Age Aged Descriptive Statistics Comparative Studies Blood Pressure Gray Matter Physiopathology Brain Stem Physiopathology Funding Source Diastolic Pressure Data Analysis Software Mann-Whitney U Test Spearman's Rank Correlation Coefficient Oxygen Saturation Adult: 19-44 years Middle Aged: 45-64 years Aged: 65+ years Male Female ab: Spinal cord injuries (SCI) often result in cardiovascular issues, increasing the risk of stroke and cognitive deficits. This study assessed cerebrovascular reactivity (CVR) using functional magnetic resonance imaging (fMRI) during a hypercapnic challenge in SCI participants compared to noninjured controls. Fourteen participants were analyzed (n = 8 with SCI [unless otherwise noted], median age = 44 years; n = 6 controls, median age = 33 years). CVR was calculated through fMRI signal changes. The results showed a longer CVR component (tau) in the grey matter of SCI participants (n = 7) compared to controls (median difference = 3.0 s; p <.05). Time since injury (TSI) correlated negatively with steady-state CVR in the grey matter and brainstem of SCI participants (RS = −0.81, p =.014; RS = −0.84, p =.009, respectively). Lower steady-state CVR in the brainstem of the SCI group (n = 7) correlated with lower diastolic blood pressure (RS = 0.76, p =.046). Higher frequency of hypotensive episodes (n = 7) was linked to lower CVR outcomes in the grey matter (RS = −0.86, p =.014) and brainstem (RS = −0.89, p =.007). Preliminary findings suggest a difference in the dynamic CVR component, tau, between the SCI and noninjured control groups, potentially explaining the higher cerebrovascular health burden in SCI individuals. Exploratory associations indicate that longer TSI, lower diastolic blood pressure, and more hypotensive episodes may lead to poorer CVR outcomes. However, further research is necessary to establish causality and support these observations. pubtype: Academic Journal doctype: diagnostic images pictorial research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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