Factors influencing clinical trial participation of women with fibromyalgia across the United States: a cross-sectional survey.
Although fibromyalgia is a widespread chronic pain condition where 90 percent of patients are women, they are underrepresented in Randomized Clinical Trials (RCTs). We aim to describe the willingness to participate, assess different factors, and explore the impact of sociodemographic and clinical ch...
| Publicado en: | Women & Health Vol. 64; no. 5; pp. 369 - 380 |
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| Autores principales: | , , , , , , , |
| Formato: | Artículo |
| Publicado: |
Taylor & Francis Ltd
May/Jun2024
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| Materias: | |
| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ssf&AN=177520304&site=ehost-live header: @attributes: shortDbName: ssf uiTerm: 177520304 longDbName: Social Sciences Full Text (H.W. Wilson) uiTag: AN controlInfo: bkinfo: jinfo: jid: 03630242 WAH jtl: Women & Health issn: 03630242 maglogo: N pubinfo: dt: May/Jun2024 vid: 64 iid: 5 pid: 377 pub: Taylor & Francis Ltd artinfo: ui: 177520304 10.1080/03630242.2024.2334700 ppf: 369 ppct: 11 formats: tig: atl: Factors influencing clinical trial participation of women with fibromyalgia across the United States: a cross-sectional survey. aug: au: Cardenas-Rojas, A. Pacheco-Barrios, K. Castelo-Branco, L. Gonzalez-Mego, P. Marduy, A. Vásquez-Ávila, K. Caumo, W. Fregni, F. affil: Neuromodulation Center and Center for Clinical Research Learning, Spaulding Rehabilitation Hospital and Massachusetts General Hospital, Harvard Medical School, Boston, USA Laboratory of Pain and Neuromodulation, Hospital de Clínicas de Porto Alegre (HCPA), Porto Alegre, Brazil su: United States Cross-sectional method Income Human research subjects Psychology of women Randomized controlled trials Age distribution Patient participation Educational attainment Pain measurement Patient selection Research funding Fibromyalgia Multiple regression analysis Questionnaires Multivariate analysis Statistics sug: subj: Cross-sectional method Income Human research subjects Psychology of women Randomized controlled trials Age distribution Patient participation Educational attainment United States Pain measurement Patient selection Research funding Fibromyalgia Multiple regression analysis Questionnaires Multivariate analysis Statistics keyword: Clinical trials participation fibromyalgia questionnaire recruitment Clinical trials participation fibromyalgia questionnaire recruitment ab: Although fibromyalgia is a widespread chronic pain condition where 90 percent of patients are women, they are underrepresented in Randomized Clinical Trials (RCTs). We aim to describe the willingness to participate, assess different factors, and explore the impact of sociodemographic and clinical characteristics on perceived barriers to trial participation. This is a cross-sectional survey targeting women with fibromyalgia. Univariate and multivariate logistic regression were performed. Of the 436 women with fibromyalgia, 56 percent were very likely to participate in RCTs. Minorities expressed less interest than non-minorities, while higher pain scores, previous participation, and younger patients reported a higher interest. Barriers significantly associated with a reduced willingness were: the participant's perception (side effects, distance, potential negative impact), the center (reputation), the trial protocol (number of visits, placebo), and trial awareness by their physician. In a multivariate analysis, older age, low education, lower income, and higher pain scores were associated with perceived barriers to RCT participation. Despite the high interest to participate, factors such as side effects, the center's distance, number of visits, placebo treatments, and the institution's reputation must be considered in clinical trials for women with fibromyalgia. pubtype: Academic Journal doctype: Article src: R language: English refInfo: copyright: @attributes: flag: N holdings: @attributes: islocal: N |
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