A biphasic response to blueberry supplementation on depressive symptoms in emerging adults: a double-blind randomized controlled trial.
Purpose: The aim of the present study was to examine the acute and chronic effects of wild blueberry supplementation on mood, executive function, and serum biomarkers of neuroplasticity, inflammation, and oxidative stress in emerging adults with moderate-to-severe depressive symptoms. Methods: In th...
| Published in: | European Journal of Nutrition Vol. 63; no. 4; pp. 1071 - 1089 |
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| Main Authors: | , , , |
| Format: | research tables/charts randomized controlled trial Journal Article |
| Published: |
Springer Nature
Jun2024
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| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=177559845&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 177559845 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 14366207 CR0 jtl: European Journal of Nutrition issn: 14366207 maglogo: N pubinfo: dt: Jun2024 vid: 63 iid: 4 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 177559845 175176776 177559845 177559845 10.1007/s00394-023-03311-9 177559845 ppf: 1071 ppct: 18 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: A biphasic response to blueberry supplementation on depressive symptoms in emerging adults: a double-blind randomized controlled trial. aug: au: Velichkov, Martin Bezur, Zsofia van Reekum, Carien M. Williams, Claire M. affil: https://ror.org/05v62cm79 School of Psychology and Clinical Language Sciences, University of Reading, Reading, UK sug: subj: Blueberry Therapeutic Use Dietary Supplementation Depression Drug Therapy Severity of Illness Affect Drug Effects Executive Function Drug Effects Biological Markers Blood Neuronal Plasticity Drug Effects Inflammation Drug Therapy Oxidative Stress Drug Effects Human Male Female Adult Randomized Controlled Trials Double-Blind Studies Self Report Random Assignment Placebos Analysis of Covariance Confidence Intervals Descriptive Statistics Psychological Tests Funding Source Adult: 19-44 years Male Female ab: Purpose: The aim of the present study was to examine the acute and chronic effects of wild blueberry supplementation on mood, executive function, and serum biomarkers of neuroplasticity, inflammation, and oxidative stress in emerging adults with moderate-to-severe depressive symptoms. Methods: In this double-blind trial, 60 emerging adults (Mage = 20.0 years, 32% male) with self-reported depressive symptoms were randomly assigned to receive a single blueberry drink (acute phase), followed by 6 weeks of daily blueberry supplementation (chronic phase), or a matched placebo drink. The primary outcome was Beck Depression Inventory-II (BDI-II) scores at 6-week follow-up. Further measures included momentary affect (PANAS-X) and accuracy on an executive function task. The data were analyzed using ANCOVAs adjusted for baseline values, sex, and habitual fruit and vegetable intake. Estimated marginal means were calculated to compare the treatment arms. Results: The blueberry drink significantly improved positive affect (p = 0.026) and executive function (p = 0.025) at 2 h post-ingestion, with change scores being positively correlated in the blueberry group (r = 0.424, p = 0.017). However, after six weeks of supplementation the reduction in BDI-II scores was greater in the placebo group by 5.8 points (95% CI: 0.8–10.7, p = 0.023). Generalized anxiety and anhedonia also decreased significantly more in the placebo group. No significant differences were found for any of the biomarkers. Conclusions: Six weeks of wild blueberry supplementation were inferior to placebo in reducing depressive symptoms. Nevertheless, the correlated improvements in positive affect and executive function after a single dose of blueberries point to a beneficial, albeit transient, psychological effect. These contrasting results suggest a biphasic, hormetic-like response that warrants further investigation. Trial registration: NCT04647019, dated 30 November, 2020. pubtype: Academic Journal doctype: research tables/charts randomized controlled trial Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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