Physical activity shifts gut microbiota structure in aged subjects with overweight/obesity and metabolic syndrome.
We aimed to identify how physical activity (PA), within the context of a Mediterranean diet, affects metabolic variables and gut microbiota in older individuals with overweight/obesity and metabolic syndrome. Observational analysis was conducted as part of the PREDIMED-Plus study with 152 males and...
| Publicado en: | Biology of Sport Vol. 41; no. 3; pp. 47 - 61 |
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| Autores principales: | , , , , , , , , , , , , , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Termedia Publishing House
2024
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=177591739&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 177591739 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 0860021X 16S3 jtl: Biology of Sport issn: 0860021X maglogo: N pubinfo: dt: 2024 vid: 41 iid: 3 pid: 24295 pub: Termedia Publishing House place: , <Blank> artinfo: ui: 177591739 177591739 177591739 10.5114/biolsport.2024.133005 177591739 ppf: 47 ppct: 14 formats: tig: atl: Physical activity shifts gut microbiota structure in aged subjects with overweight/obesity and metabolic syndrome. aug: au: Ruiz-Limón, Patricia Muralidharan, Jananee Gomez-Perez, Ana M. Murri, Mora Vioque, Jesús Corella, Dolores Fitó, Montse Vidal, Josep Salas-Salvadó, Jordi Torres-Collado, Laura Coltell, Oscar Atzeni, Alessandro Castañer, Olga Bulló, Mònica Bernal-López, M. Rosa Moreno-Indias, Isabel Tinahones, Francisco J. affil: Department of Endocrinology and Nutrition, Virgen de la Victoria University Hospital, The Biomedical Research Institute of Malaga and Platform in Nanomedicine (IBIMA BIONAND Platform), University of Malaga, 29016 Malaga, Spain sug: subj: Physical Activity Evaluation Mediterranean Diet Gut Microbiota Metabolism Obesity In Old Age Metabolic Syndrome X In Old Age Human Nonexperimental Studies Female Male Anthropometry RNA Sequence Analysis Life Style Middle Age Aged Funding Source Middle Aged: 45-64 years Aged: 65+ years Female Male ab: We aimed to identify how physical activity (PA), within the context of a Mediterranean diet, affects metabolic variables and gut microbiota in older individuals with overweight/obesity and metabolic syndrome. Observational analysis was conducted as part of the PREDIMED-Plus study with 152 males and 145 females with overweight/obesity and metabolic syndrome. General assessments, anthropometric and biochemical measurements, and gut microbial 16S rRNA sequencing data were analyzed at baseline and 1-year of follow-up. Participants were stratified by tertiles of 1-year change in total PA-related energy expenditure ranging from -98.77 to 1099.99 METs (min/week). The total PA percentage of change was reduced in tertile 1 (-44.83 ± 24.94), increased in tertile 2 (28.96 ± 23.33) and tertile 3 (273.64 ± 221.42). Beta diversity analysis showed differences in the gut microbiota population within each tertile group. Significant differences were found at phylum, family, and genus levels in the gut microbiota of the three tertile groups at baseline and 1-year timepoint. Tertile 3, the group with the greatest increase in PA, was characterized by increases in their levels of Sutterella, Bilophila, and Lachnospira bacteria as well as a reduction in Collinsella. Moreover, this tertile showed a different pattern in its predicted metabolic capacities to the other groups. Our results have demonstrated that changes in PA such as lifestyle and Mediterranean diet induces specific variations in the gut microbiota profile. This modulation of gut microbiome populations and their metabolic capacities may contribute to the health of the aged individuals with overweight/obesity and metabolic syndrome. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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