An Investigation of Age-related Neuropathophysiology in Autism Spectrum Disorder Using Fixel-based Analysis of Corpus Callosum White Matter Micro- and Macrostructure.
Fixel-based analysis was used to probe age-related changes in white matter micro- and macrostructure of the corpus callosum between participants with (N = 54) and without (N = 50) autism spectrum disorder (ASD). Data were obtained from the Autism Brain Imaging Data Exchange-II (ABIDE-II). Compared t...
| Publicado en: | Journal of Autism & Developmental Disorders Vol. 54; no. 6; pp. 2198 - 2211 |
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| Autores principales: | , , , , , , , |
| Formato: | pictorial research tables/charts Journal Article |
| Publicado: |
Springer Nature
Jun2024
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=177598725&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 177598725 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 01623257 AUT jtl: Journal of Autism & Developmental Disorders issn: 01623257 maglogo: N pubinfo: dt: Jun2024 vid: 54 iid: 6 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 177598725 163204099 177598725 177598725 10.1007/s10803-023-05980-1 177598725 ppf: 2198 ppct: 13 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: An Investigation of Age-related Neuropathophysiology in Autism Spectrum Disorder Using Fixel-based Analysis of Corpus Callosum White Matter Micro- and Macrostructure. aug: au: Kirkovski, Melissa Singh, Mervyn Dhollander, Thijs Fuelscher, Ian Hyde, Christian Albein-Urios, Natalia Donaldson, Peter H Enticott, Peter G affil: https://ror.org/02czsnj07 Cognitive Neuroscience Unit, School of Psychology, Deakin University, Geelong, VIC, Australia sug: subj: Age Factors Autism Spectrum Disorder Physiopathology Telencephalon Physiopathology White Matter Physiopathology Human Child, Preschool Child Adolescence Young Adult Prospective Studies Female Male Comparative Studies Magnetic Resonance Imaging Child, Preschool: 2-5 years Child: 6-12 years Adolescent: 13-18 years Female Male ab: Fixel-based analysis was used to probe age-related changes in white matter micro- and macrostructure of the corpus callosum between participants with (N = 54) and without (N = 50) autism spectrum disorder (ASD). Data were obtained from the Autism Brain Imaging Data Exchange-II (ABIDE-II). Compared to age-matched controls, young adolescents with ASD (11.19 ± 7.54 years) showed reduced macroscopic fiber cross-section (logFC) and combined fiber-density and cross-section (FDC). Reduced fiber-density (FD) and FDC was noted in a marginally older (13.87 ± 3.15 years) ASD cohort. Among the oldest ASD cohort (17.07 ± 3.56 years), a non-significant trend indicative of reduced FD was noted. White matter aberration appears greatest and most widespread among younger ASD cohorts. This supports the suggestion that some early neuropathophysiological indicators in ASD may dissipate with age. pubtype: Academic Journal doctype: pictorial research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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