Characterizing the temporal dynamics of intrinsic brain activities in depressed adolescents with prior suicide attempts.
Converging evidence has revealed disturbances in the corticostriatolimic system are associated with suicidal behaviors in adults with major depressive disorder. However, the neurobiological mechanism that confers suicidal vulnerability in depressed adolescents is largely unknown. A total of 86 depre...
| Publicado en: | European Child & Adolescent Psychiatry Vol. 33; no. 4; pp. 1179 - 1192 |
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| Autores principales: | , , , , , , , , , , , , , , , , |
| Formato: | pictorial research tables/charts Journal Article |
| Publicado: |
Springer Nature
Apr2024
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=177625045&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 177625045 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 10188827 EJ3 jtl: European Child & Adolescent Psychiatry issn: 10188827 maglogo: N pubinfo: dt: Apr2024 vid: 33 iid: 4 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 177625045 164148212 177625045 177625045 10.1007/s00787-023-02242-4 177625045 ppf: 1179 ppct: 13 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Characterizing the temporal dynamics of intrinsic brain activities in depressed adolescents with prior suicide attempts. aug: au: Cheng, Xiaofang Chen, Jianshan Zhang, Xiaofei Wang, Ting sun, Jiaqi Zhou, Yanling Yang, Ruilan Xiao, Yeyu Chen, Amei Song, Ziyi Chen, Pinrui Yang, Chanjuan QiuxiaWu Lin, Taifeng Chen, Yingmei Cao, Liping Wei, Xinhua affil: The Affiliated Brain Hospital of Guangzhou Medical University, 36 Mingxin Road, liwan district, 510370, Guangzhou, Guangdong, People's Republic of China sug: subj: Suicide, Attempted Risk Factors Depression Physiopathology Brain Physiopathology Human Relaxation Magnetic Resonance Imaging Methods Temporal Lobe Physiopathology Prefrontal Cortex Physiopathology Frontal Lobe Physiopathology Insular Cortex Physiopathology Recurrence Risk Factors Prediction Models Emotions Decision Making Disease Susceptibility Biological Markers Funding Source Adolescence Adolescent: 13-18 years ab: Converging evidence has revealed disturbances in the corticostriatolimic system are associated with suicidal behaviors in adults with major depressive disorder. However, the neurobiological mechanism that confers suicidal vulnerability in depressed adolescents is largely unknown. A total of 86 depressed adolescents with and without prior suicide attempts (SA) and 47 healthy controls underwent resting-state functional imaging (R-fMRI) scans. The dynamic amplitude of low-frequency fluctuations (dALFF) was measured using sliding window approach. We identified SA-related alterations in dALFF variability primarily in the left middle temporal gyrus, inferior frontal gyrus, middle frontal gyrus (MFG), superior frontal gyrus (SFG), right SFG, supplementary motor area (SMA) and insula in depressed adolescents. Notably, dALFF variability in the left MFG and SMA was higher in depressed adolescents with recurrent suicide attempts than in those with a single suicide attempt. Moreover, dALFF variability was capable of generating better diagnostic and prediction models for suicidality than static ALFF. Our findings suggest that alterations in brain dynamics in regions involved in emotional processing, decision-making and response inhibition are associated with an increased risk of suicidal behaviors in depressed adolescents. Furthermore, dALFF variability could serve as a sensitive biomarker for revealing the neurobiological mechanisms underlying suicidal vulnerability. pubtype: Academic Journal doctype: pictorial research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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