Development and Validation of a 3D Resnet Model for Prediction of Lymph Node Metastasis in Head and Neck Cancer Patients.
The accurate diagnosis and staging of lymph node metastasis (LNM) are crucial for determining the optimal treatment strategy for head and neck cancer patients. We aimed to develop a 3D Resnet model and investigate its prediction value in detecting LNM. This study enrolled 156 head and neck cancer pa...
| Publicado en: | Journal of Digital Imaging Vol. 37; no. 2; pp. 679 - 688 |
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| Autores principales: | , , , , , , , |
| Formato: | diagnostic images research tables/charts Journal Article |
| Publicado: |
Springer Nature
Apr2024
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=177625989&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 177625989 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 08971889 DOQ jtl: Journal of Digital Imaging issn: 08971889 maglogo: N pubinfo: dt: Apr2024 vid: 37 iid: 2 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 177625989 177625989 177625989 10.1007/s10278-023-00938-2 177625989 ppf: 679 ppct: 9 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Development and Validation of a 3D Resnet Model for Prediction of Lymph Node Metastasis in Head and Neck Cancer Patients. aug: au: Lin, Yi-Hui Lin, Chieh-Ting Chang, Ya-Han Lin, Yen-Yu Chen, Jen-Jee Huang, Chun-Rong Hsu, Yu-Wei You, Weir-Chiang affil: https://ror.org/00e87hq62 Department of Radiation Oncology, Taichung Veterans General Hospital, Taichung City, Taiwan sug: subj: Head and Neck Neoplasms Lymph Nodes Pathology Neoplasm Metastasis Diagnosis Diagnosis, Computer Assisted Imaging, Three-Dimensional Deep Learning Neural Networks (Computer) Program Development Program Evaluation Human Female Male Cancer Patients Decision Making, Clinical Image Processing, Computer Assisted Neoplasm Staging Radiologists Adult Middle Age Aged Aged, 80 and Over Sensitivity and Specificity ROC Curve Descriptive Statistics Funding Source Adult: 19-44 years Middle Aged: 45-64 years Aged: 65+ years Aged, 80 & over Female Male ab: The accurate diagnosis and staging of lymph node metastasis (LNM) are crucial for determining the optimal treatment strategy for head and neck cancer patients. We aimed to develop a 3D Resnet model and investigate its prediction value in detecting LNM. This study enrolled 156 head and neck cancer patients and analyzed 342 lymph nodes segmented from surgical pathologic reports. The patients' clinical and pathological data related to the primary tumor site and clinical and pathology T and N stages were collected. To predict LNM, we developed a dual-pathway 3D Resnet model incorporating two Resnet models with different depths to extract features from the input data. To assess the model's performance, we compared its predictions with those of radiologists in a test dataset comprising 38 patients. The study found that the dimensions and volume of LNM + were significantly larger than those of LNM-. Specifically, the Y and Z dimensions showed the highest sensitivity of 84.6% and specificity of 72.2%, respectively, in predicting LNM +. The analysis of various variations of the proposed 3D Resnet model demonstrated that Dual-3D-Resnet models with a depth of 34 achieved the highest AUC values of 0.9294. In the validation test of 38 patients and 86 lymph nodes dataset, the 3D Resnet model outperformed both physical examination and radiologists in terms of sensitivity (80.8% compared to 50.0% and 91.7%, respectively), specificity(90.0% compared to 88.5% and 65.4%, respectively), and positive predictive value (77.8% compared to 66.7% and 55.0%, respectively) in detecting individual LNM +. These results suggest that the 3D Resnet model can be valuable for accurately identifying LNM + in head and neck cancer patients. A prospective trial is needed to evaluate further the role of the 3D Resnet model in determining LNM + in head and neck cancer patients and its impact on treatment strategies and patient outcomes. pubtype: Academic Journal doctype: diagnostic images research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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