Enhancing Disease Classification with Deep Learning: a Two-Stage Optimization Approach for Monkeypox and Similar Skin Lesion Diseases.

Monkeypox (MPox) is an infectious disease caused by the monkeypox virus, presenting challenges in accurate identification due to its resemblance to other diseases. This study introduces a deep learning-based method to distinguish visually similar diseases, specifically MPox, chickenpox, and measles,...

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Published in:Journal of Digital Imaging Vol. 37; no. 2; pp. 778 - 801
Main Author: Savaş, Serkan
Format: diagnostic images equations & formulas pictorial research tables/charts Journal Article
Published: Springer Nature Apr2024
Online Access:View this record in EBSCOhost
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      dt: Apr2024
      vid: 37
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      pub: Springer Nature
      place: New York, New York
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        177625992
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        10.1007/s10278-023-00941-7
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        atl: Enhancing Disease Classification with Deep Learning: a Two-Stage Optimization Approach for Monkeypox and Similar Skin Lesion Diseases.
      aug:
        au: Savaş, Serkan
        affil: https://ror.org/01zhwwf82 Department of Computer Engineering, Kırıkkale University, 71450, Kırıkkale, Turkey
      sug:
        subj:
          Monkeypox Pathology
          Skin Neoplasms Pathology
          Monkeypox Classification
          Skin Neoplasms Classification
          Disease Attributes
          Deep Learning
          Human
          Chickenpox
          Measles
          Disease Outbreaks
          Neural Networks (Computer)
          Validation Studies
          Monkeypox Diagnosis
          Skin Neoplasms Diagnosis
          Sensitivity and Specificity
          Medical Informatics
      ab: Monkeypox (MPox) is an infectious disease caused by the monkeypox virus, presenting challenges in accurate identification due to its resemblance to other diseases. This study introduces a deep learning-based method to distinguish visually similar diseases, specifically MPox, chickenpox, and measles, addressing the 2022 global MPox outbreak. A two-stage optimization approach was presented in the study. By analyzing pre-trained deep neural networks including 71 models, this study optimizes accuracy through transfer learning, fine-tuning, and ensemble learning techniques. ConvNeXtBase, Large, and XLarge models were identified achieving 97.5% accuracy in the first stage. Afterwards, some selection criteria were followed for the models identified in the first stage for use in ensemble learning technique within the optimization approach. The top-performing ensemble model, EM3 (composed of RegNetX160, ResNetRS101, and ResNet101), attains an AUC of 0.9971 in the second stage. Evaluation on unseen data ensures model robustness and enhances the study's overall validity and reliability. The design and implementation of the study have been optimized to address the limitations identified in the literature. This approach offers a rapid and highly accurate decision support system for timely MPox diagnosis, reducing human error, manual processes, and enhancing clinic efficiency. It aids in early MPox detection, addresses diverse disease challenges, and informs imaging device software development. The study's broad implications support global health efforts and showcase artificial intelligence potential in medical informatics for disease identification and diagnosis.
      pubtype: Academic Journal
      doctype:
        diagnostic images
        equations & formulas
        pictorial
        research
        tables/charts
        Journal Article
      ougenre: Article
    language: English
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