Reliable Delineation of Clinical Target Volumes for Cervical Cancer Radiotherapy on CT/MR Dual-Modality Images.

Accurate delineation of the clinical target volume (CTV) is a crucial prerequisite for safe and effective radiotherapy characterized. This study addresses the integration of magnetic resonance (MR) images to aid in target delineation on computed tomography (CT) images. However, obtaining MR images d...

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Publicado en:Journal of Digital Imaging Vol. 37; no. 2; pp. 575 - 589
Autores principales: Sun, Ying, Wang, Yuening, Gan, Kexin, Wang, Yuxin, Chen, Ying, Ge, Yun, Yuan, Jie, Xu, Hanzi
Formato: diagnostic images equations & formulas research tables/charts Journal Article
Publicado: Springer Nature Apr2024
Acceso en línea:Ver este registro en EBSCOhost
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      dt: Apr2024
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      pub: Springer Nature
      place: New York, New York
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        10.1007/s10278-023-00951-5
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        atl: Reliable Delineation of Clinical Target Volumes for Cervical Cancer Radiotherapy on CT/MR Dual-Modality Images.
      aug:
        au:
          Sun, Ying
          Wang, Yuening
          Gan, Kexin
          Wang, Yuxin
          Chen, Ying
          Ge, Yun
          Yuan, Jie
          Xu, Hanzi
        affil: https://ror.org/01rxvg760 School of Electronic Science and Engineering, Nanjing University, Nanjing, China
      sug:
        subj:
          Cervix Neoplasms Radiography
          Radiotherapy, Conformal Methods
          Tomography, X-Ray Computed Methods
          Magnetic Resonance Imaging Methods
          Therapy, Computer Assisted Methods
          Image Processing, Computer Assisted
          Image Enhancement
          Quality Improvement
          Models, Statistical
          Artificial Intelligence
      ab: Accurate delineation of the clinical target volume (CTV) is a crucial prerequisite for safe and effective radiotherapy characterized. This study addresses the integration of magnetic resonance (MR) images to aid in target delineation on computed tomography (CT) images. However, obtaining MR images directly can be challenging. Therefore, we employ AI-based image generation techniques to "intelligentially generate" MR images from CT images to improve CTV delineation based on CT images. To generate high-quality MR images, we propose an attention-guided single-loop image generation model. The model can yield higher-quality images by introducing an attention mechanism in feature extraction and enhancing the loss function. Based on the generated MR images, we propose a CTV segmentation model fusing multi-scale features through image fusion and a hollow space pyramid module to enhance segmentation accuracy. The image generation model used in this study improves the peak signal-to-noise ratio (PSNR) and structural similarity index (SSIM) from 14.87 and 0.58 to 16.72 and 0.67, respectively, and improves the feature distribution distance and learning-perception image similarity from 180.86 and 0.28 to 110.98 and 0.22, achieving higher quality image generation. The proposed segmentation method demonstrates high accuracy, compared with the FCN method, the intersection over union ratio and the Dice coefficient are improved from 0.8360 and 0.8998 to 0.9043 and 0.9473, respectively. Hausdorff distance and mean surface distance decreased from 5.5573 mm and 2.3269 mm to 4.7204 mm and 0.9397 mm, respectively, achieving clinically acceptable segmentation accuracy. Our method might reduce physicians' manual workload and accelerate the diagnosis and treatment process while decreasing inter-observer variability in identifying anatomical structures.
      pubtype: Academic Journal
      doctype:
        diagnostic images
        equations & formulas
        research
        tables/charts
        Journal Article
      ougenre: Article
    language: English
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