Abnormalities of regional brain activity and executive function in patients with temporal lobe epilepsy: A cross-sectional and longitudinal resting-state functional MRI study.
Purpose: We decided to track changes in regional brain activity and executive function in temporal lobe epilepsy (TLE) patients based on cross-sectional and longitudinal designs and sought potential imaging features for follow-up observation. Methods: Thirty-two TLE patients and thirty-three healthy...
| Publicado en: | Neuroradiology Vol. 66; no. 7; pp. 1093 - 1105 |
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| Autores principales: | , , , , |
| Formato: | diagnostic images research tables/charts Journal Article |
| Publicado: |
Springer Nature
Jul2024
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=177648394&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 177648394 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00283940 NYZ jtl: Neuroradiology issn: 00283940 maglogo: N pubinfo: dt: Jul2024 vid: 66 iid: 7 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 177648394 176830499 177648394 177648394 10.1007/s00234-024-03368-1 177648394 ppf: 1093 ppct: 12 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Abnormalities of regional brain activity and executive function in patients with temporal lobe epilepsy: A cross-sectional and longitudinal resting-state functional MRI study. aug: au: Huang, Huachun Huang, Dongying Luo, Cuimi Qiu, Zhuoyan Zheng, Jinou affil: https://ror.org/030sc3x20 Department of Neurology, the First Affiliated Hospital of Guangxi Medical University, Nanning, China sug: subj: Executive Function Magnetic Resonance Imaging Methods Brain Physiopathology Epilepsy, Temporal Lobe Physiopathology Neuroradiography Brain Mapping Methods Human Cross Sectional Studies Prospective Studies Multivariate Analysis Case Control Studies Prefrontal Cortex Basal Ganglia China Correlational Studies Time Factors Funding Source Descriptive Statistics Male Female Adult Adult: 19-44 years Male Female ab: Purpose: We decided to track changes in regional brain activity and executive function in temporal lobe epilepsy (TLE) patients based on cross-sectional and longitudinal designs and sought potential imaging features for follow-up observation. Methods: Thirty-two TLE patients and thirty-three healthy controls (HCs) were recruited to detect changes in fractional amplitude of low-frequency fluctuation (fALFF) and regional homogeneity (ReHo) and to evaluate executive function both at baseline and at two-year (23.3 ± 8.3 months) follow-up. Moreover, multivariate pattern analysis (MVPA) was used for follow-up observation. Results: TLE patients displayed lower fALFF values in the right superior frontal gyrus (SFG) and higher ReHo values in the left putamen (PUT) relative to the HCs. Longitudinal analysis revealed that TLE patients at follow-up exhibited higher fALFF values in the left postcentral gyrus (PoCG), higher ReHo values in the left PoCG and the right middle frontal gyrus (MFG), lower ReHo values in the bilateral PUT and the right fusiform gyrus (FFG) compared with these patients at baseline. The executive function was impaired in TLE patients but didn't deteriorate over time. No correlations were discovered between regional brain activity and executive function. The MVPA based on ReHo performed well in differentiating the follow-up group from the baseline group. Conclusion: We revealed the abnormalities in regional brain activity and executive function as well as their longitudinal trends in TLE patients. The ReHo might be a good imaging feature for follow-up observation. pubtype: Academic Journal doctype: diagnostic images research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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