Effect of a Ventilatory Assist Device in Addition to Supplemental Oxygen on Exercise Endurance in Subjects With COPD.
BACKGROUND: This study assessed the clinical effects of a ventilatory assist (VA) device in addition to supplemental O2 (VA+O2) on exercise endurance in subjects with severe to very severe COPD managed with long-term oxygen therapy (LTOT). METHODS: This was a crossover clinical feasibility study of...
| Publicado en: | Respiratory Care Vol. 69; no. 5; pp. 527 - 534 |
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| Autores principales: | , , , , , , |
| Formato: | CEU research tables/charts Journal Article |
| Publicado: |
Mary Ann Liebert, Inc.
May2024
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=177673045&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 177673045 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00201324 4GG jtl: Respiratory Care issn: 00201324 maglogo: N pubinfo: dt: May2024 vid: 69 iid: 5 pid: 1365 pub: Mary Ann Liebert, Inc. place: New Rochelle, New York artinfo: ui: 177673045 177673045 177673045 10.4187/respcare.10875 177673045 ppf: 527 ppct: 7 formats: fmt: @attributes: type: P tig: atl: Effect of a Ventilatory Assist Device in Addition to Supplemental Oxygen on Exercise Endurance in Subjects With COPD. aug: au: Hilling, Lana Cayou, Cindy Kops, Richard S. Ameo, Robert A. Morishige, Richard J. Glezer, Stanislav Hill, Nicholas S. affil: John Muir Health Pulmonary Rehabilitation Program, Concord, California sug: subj: Pulmonary Disease, Chronic Obstructive Physical Endurance Exercise Physiology Respiration, Artificial Equipment and Supplies Severity of Illness Oxygen Therapy Long Term Care Treatment Outcomes Human Male Female Middle Age Aged Crossover Design Pilot Studies Descriptive Statistics Data Analysis Software Funding Source Education, Continuing (Credit) Middle Aged: 45-64 years Aged: 65+ years Male Female ab: BACKGROUND: This study assessed the clinical effects of a ventilatory assist (VA) device in addition to supplemental O2 (VA+O2) on exercise endurance in subjects with severe to very severe COPD managed with long-term oxygen therapy (LTOT). METHODS: This was a crossover clinical feasibility study of the effects of VA+O2 in subjects with severe to very severe COPD managed with LTOT (N = 15). At visit 1, physiologic measures were obtained, and subjects were tested on the cycle ergometer with VA. Peak work rate and flow for continuous supplemental O2/VA+O2 were established. At visit 2, subjects exercised at a constant work rate of 80% peak work rate to maximum endurance after allocation to VA+O2 or O2. Cardiorespiratory variables, work rate, and dyspnea were included to define potential clinical benefits of VA+O2. Data were analyzed using a linear mixed model. RESULTS: Fifteen subjects with COPD (mean ± SD, age 67.9 ± 9.0 y, FEV1 0.89 ± 0.35 observed) completed the study. Exercise duration in minutes was significantly longer with VA+O2 versus O2 (least squares mean [standard error], 12.0 [2.0] vs 6.2 [2.0], P = .01). VA+O2 versus O2 was also associated with significantly greater isotime improvements in Borg dyspnea scores (3.6 [0.5] vs 5.7 [0.5], P < .001), SpO2 (96.9 [0.9] vs 91.4 [0.9], P < .001), leg fatigue scores (3.8 [0.6] vs 5.2 [0.6], P = .008), and breathing frequency (22.8 [0.9] vs 25.8 [0.9] breaths/min, P = .01). There were no differences in heart rate. CONCLUSIONS: In symptomatic subjects with severe to very severe COPD, VA+O2 significantly increased exercise time and improved dyspnea, SpO2, breathing frequency, and leg fatigue versus O2 alone pubtype: Academic Journal doctype: CEU research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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