Effects of estrogen on spatial navigation and memory.
Rationale: Animal studies suggest that the so-called "female" hormone estrogen enhances spatial navigation and memory. This contradicts the observation that males generally out-perform females in spatial navigation and tasks involving spatial memory. A closer look at the vast number of studies actua...
| Publicado en: | Psychopharmacology Vol. 241; no. 5; pp. 1037 - 1064 |
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| Autores principales: | , , , , , , , , |
| Formato: | Journal Article |
| Publicado: |
Springer Nature
May2024
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=177776116&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 177776116 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00333158 EJD jtl: Psychopharmacology issn: 00333158 maglogo: N pubinfo: dt: May2024 vid: 241 iid: 5 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 177776116 175666637 10.1007/s00213-024-06539-3 177776116 ppf: 1037 ppct: 27 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Effects of estrogen on spatial navigation and memory. aug: au: Joue, Gina Navarro-Schröder, Tobias Achtzehn, Johannes Moffat, Scott Hennies, Nora Fuß, Johannes Döller, Christian Wolbers, Thomas Sommer, Tobias affil: https://ror.org/01zgy1s35 Institute of Systems Neuroscience, University Medical Center Hamburg-Eppendorf, Martinistraße 52, 20246, Hamburg, Germany sug: ab: Rationale: Animal studies suggest that the so-called "female" hormone estrogen enhances spatial navigation and memory. This contradicts the observation that males generally out-perform females in spatial navigation and tasks involving spatial memory. A closer look at the vast number of studies actually reveals that performance differences are not so clear. Objectives: To help clarify the unclear performance differences between men and women and the role of estrogen, we attempted to isolate organizational from activational effects of estrogen on spatial navigation and memory. Methods: In a double-blind, placebo-controlled study, we tested the effects of orally administered estradiol valerate (E2V) in healthy, young women in their low-hormone menstrual cycle phase, compared to healthy, young men. Participants performed several first-person, environmentally rich, 3-D computer games inspired by spatial navigation and memory paradigms in animal research. Results: We found navigation behavior suggesting that sex effects dominated any E2 effects with men performing better with allocentric strategies and women with egocentric strategies. Increased E2 levels did not lead to general improvements in spatial ability in either sex but to behavioral changes reflecting navigation flexibility. Conclusion: Estrogen-driven differences in spatial cognition might be better characterized on a spectrum of navigation flexibility rather than by categorical performance measures or skills. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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