Efficacy of a Food Supplement Containing Lactobacillus acidophilus LA14, Peptides, and a Multivitamin Complex in Improving Gastroesophageal Reflux Disease-Related Outcomes and Quality of Life of Subjects Showing Mild-to-Moderate Gastroesophageal Reflux Disease
Dietary interventions represent an interesting alternative to pharmacological treatments for improving the quality of life (QoL) of subjects suffering from gastroesophageal reflux disease (GERD). This randomized, double-blind, placebo-controlled study aimed to evaluate the efficacy of a food supplem...
| Publicado en: | Nutrients Vol. 16; no. 11; pp. 1759 - 1769 |
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| Autores principales: | , , , , , |
| Formato: | research tables/charts randomized controlled trial Journal Article |
| Publicado: |
MDPI
Jun2024
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=177869008&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 177869008 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 20726643 B0TT jtl: Nutrients issn: 20726643 maglogo: N pubinfo: dt: Jun2024 vid: 16 iid: 11 pid: 97109 pub: MDPI artinfo: ui: 177869008 177869008 177869008 10.3390/nu16111759 177869008 ppf: 1759 ppct: 10 formats: tig: atl: Efficacy of a Food Supplement Containing Lactobacillus acidophilus LA14, Peptides, and a Multivitamin Complex in Improving Gastroesophageal Reflux Disease-Related Outcomes and Quality of Life of Subjects Showing Mild-to-Moderate Gastroesophageal Reflux Disease aug: au: Tursi, Francesco Benedetto, Edoardo Spina, Amelia De Ponti, Ileana Amone, Fabio Nobile, Vincenzo affil: Research and Development, Complife Italia S.r.l., 27028 San Martino Siccomario, Italy sug: subj: Gastroesophageal Reflux Symptoms Gastroesophageal Reflux Diet Therapy Dietary Supplementation Lactobacillus Acidophilus Probiotics Therapeutic Use Bioactive Peptides Therapeutic Use Vitamins Therapeutic Use Drugs, Non-Prescription Therapeutic Use Quality of Life Treatment Outcomes Human Randomized Controlled Trials Random Assignment Adult Female Male Heartburn Diet Therapy Questionnaires Self Assessment Funding Source Adult: 19-44 years Female Male ab: Dietary interventions represent an interesting alternative to pharmacological treatments for improving the quality of life (QoL) of subjects suffering from gastroesophageal reflux disease (GERD). This randomized, double-blind, placebo-controlled study aimed to evaluate the efficacy of a food supplement (FS) containing a probiotic strain, bioactive peptides, and vitamins in relieving heartburn/dyspeptic symptoms in subjects with mild-to-moderate GERD. Fifty-six adult participants were randomly assigned to receive the placebo or the active FS for 28 days. Subjects were asked to record daily the frequency and intensity of heartburn episodes and the intake of over- the-counter (OTC) medications. GERD-QoL and self-assessment questionnaires were also completed every two weeks and at the end of the treatment, respectively. FS was effective in achieving a progressive and significant reduction of heartburn frequency and severity, with an intergroup significant difference at the end of the treatment period. FS group also reported a reduction in the OTC medication intake, whereas placebo administration did not modify the OTC intake. Results from the QoL and self-assessment questionnaires showed that FS administration achieved a progressive and statistically significant intragroup and intergroup improvement in the QoL score and a higher positive response with respect to the placebo treatment. pubtype: Academic Journal doctype: research tables/charts randomized controlled trial Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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