Cover Image
QR Code

HEPATITIS AUTOINMUNE SERONEGATIVA.

Autoimmune hepatitis (AIH) is a rare, chronic, inflammatory, and necrotic liver disease characterized by the presence of autoantibodies. Its etiology is unknown. It affects 1 in 200 000 people annually in the US and occurs predominantly in women. Its presentation varies from asymptomatic forms to ci...

Full description

Published in:Medicina (Buenos Aires) Vol. 84; no. 3; pp. 534 - 544
Main Authors: Gómez Pastrana, Juan Carlos, Beleño, Álvaro, Martinez, Mauricio, Cavanagh, Ignacio, Jimenez, Juan
Format: Article
Published: Medicina (Buenos Aires) may/jun2024
Online Access:View this record in EBSCOhost
fields @attributes:
  recordID: 1
pdfLink:
plink: https://search.ebscohost.com/login.aspx?direct=true&db=lth&AN=177911998&site=ehost-live
header:
  @attributes:
    shortDbName: lth
    uiTerm: 177911998
    longDbName: MedicLatina
    uiTag: AN
  controlInfo:
    bkinfo:
    jinfo:
      jid:
        00257680
        50C2
      jtl: Medicina (Buenos Aires)
      issn: 00257680
      maglogo: N
    pubinfo:
      dt: may/jun2024
      vid: 84
      iid: 3
      pid: 39353
      pub: Medicina (Buenos Aires)
    artinfo:
      ui: 177911998
      ppf: 534
      ppct: 10
      formats:
        fmt:
          – @attributes:
              type: T
          – @attributes:
              type: P
              size: 902KB
      tig:
        atl: HEPATITIS AUTOINMUNE SERONEGATIVA.
      aug:
        au:
          Gómez Pastrana, Juan Carlos
          Beleño, Álvaro
          Martinez, Mauricio
          Cavanagh, Ignacio
          Jimenez, Juan
        affil: Departamento de Medicina Interna, Hospital Universitario Fundación Sanatorio Güemes, Buenos Aires, Argentina
      sug:
      keyword:
        Autoantinuclear antibodies (ANA)
        Autoimmune hepatitis
        azathioprine
        MeSH
        Seronegative
        Autoanticuer pos antinucleares (ANA)
        autoanticuerpos antinucleares (ANA)
        autoantinuclear antibodies (ANA)
        autoimmune hepatitis
        azathioprine
        Azatioprina
        DeCS
        Hepatitis autoinmune
        MeSH
        Seronegativa
        seronegative
      ab:
        Autoimmune hepatitis (AIH) is a rare, chronic, inflammatory, and necrotic liver disease characterized by the presence of autoantibodies. Its etiology is unknown. It affects 1 in 200 000 people annually in the US and occurs predominantly in women. Its presentation varies from asymptomatic forms to cirrhosis and acute liver failure and its diagnosis is based on the measurement of autoantibodies, such as antinuclear autoantibodies (ANA), anti-smooth muscle antibodies (ASMA) and anti-liver and kidney microsomal antibodies (anti-LKM). 1). 10% of HAIs do not present antibodies, being called seronegative HAI, requiring a liver biopsy for diagnosis. To date the evidence remains limited and different societies have issued suggestions and recommendations. For this reason, we believe it is relevant to carry out a bibliographic review on the subject, capturing in this document the important information for the understanding and management of this pathology.
        La hepatitis autoinmune (HAI) es una enfermedad inflamatoria y necrótica del hígado, crónica e infrecuente caracterizada por la presencia de autoanticuerpos. Su etiología es desconocida. Afecta a 1 de cada 200 000 personas anualmente en los EE. UU. y se presenta predominantemente en mujeres. Su presentación varía desde formas asintomáticas hasta la cirrosis y falla hepática aguda y su diagnóstico se basa en la medición de autoanticuerpos, como los autoanticuerpos antinucleares (ANA), anticuerpos antimúsculo liso (ASMA) y anticuerpos antimicrosomales de hígado y riñón (anti-LKM-1). El 10% de las HAI no presentan anti-cuerpos, denominándose HAI seronegativa, necesitando biopsia hepática para el diagnóstico. Hasta la fecha la evidencia sigue siendo limitada y diferentes sociedades han emitido sugerencias y recomendaciones. Por tal motivo creemos relevante realizar una revisión bibliográfica sobre el tema plasmando en este documento la información importante para la compresión y el manejo de esta patología.
      pubtype: Academic Journal
      doctype: Article
      src: R
    language: Spanish
    refInfo:
    copyright:
      @attributes:
        flag: Y
      custom: Copyright of Medicina (Buenos Aires) is the property of Medicina (Buenos Aires) and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use.
      item: Medicina (Buenos Aires)
      holder: Medicina (Buenos Aires)
      dt:
        @attributes:
          year: 2024
    holdings:
      @attributes:
        islocal: N