Association of metabolic syndrome and its components with Parkinson's disease: a cross-sectional study.
Background: The interrelation between metabolic syndrome (MetS) and Parkinson's disease (PD) likely arises from shared pathological mechanisms. This study thus aims to examine the impact of MetS and its components on PD. Methods: This study utilized data extracted from the National Health and Nutrit...
| Publicado en: | BMC Endocrine Disorders Vol. 24; no. 1; pp. 1 - 9 |
|---|---|
| Autores principales: | , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
BioMed Central
6/19/2024
|
| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=177963694&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 177963694 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 14726823 1CHL jtl: BMC Endocrine Disorders issn: 14726823 maglogo: N pubinfo: dt: 6/19/2024 vid: 24 iid: 1 pid: 24147 pub: BioMed Central artinfo: ui: 177963694 177963694 177963694 10.1186/s12902-024-01623-3 177963694 ppf: 1 ppct: 8 formats: tig: atl: Association of metabolic syndrome and its components with Parkinson's disease: a cross-sectional study. aug: au: Shi, Yue Zhang, XueYi Feng, Yue Yue, ZongXiang affil: Chengdu University of Traditional Chinese Medicine, Chengdu, China sug: subj: Metabolic Syndrome X Parkinson Disease Human Male Female Adolescence Adult Middle Age Descriptive Statistics Cross Sectional Studies Algorithms Triglycerides Lipoproteins, HDL Cholesterol Coffee Alcohol Drinking Hyperlipidemia Waist Circumference Multiple Logistic Regression Odds Ratio Confidence Intervals Hypertension Diabetes Mellitus Adolescent: 13-18 years Adult: 19-44 years Middle Aged: 45-64 years Male Female ab: Background: The interrelation between metabolic syndrome (MetS) and Parkinson's disease (PD) likely arises from shared pathological mechanisms. This study thus aims to examine the impact of MetS and its components on PD. Methods: This study utilized data extracted from the National Health and Nutrition Examination Survey database spanning 1999 to 2020. The random forest algorithm was applied to fill in the missing data. Propensity score optimal full matching was conducted. The data were adjusted by total weights derived from both sampling and matching weights. The weighted data were utilized to create multifactor logistic regression models. Odds ratios (ORs) and average marginal effects, along with their corresponding 95% confidence intervals (CIs), were calculated. Results: MetS did not significantly affect the risk of PD (OR: 1.01; 95% CI: 0.77, 1.34; P = 0.92). Hypertension elevated the risk of PD (OR: 1.33; 95% CI: 1.01, 1.76; P = 0.045), accompanied by a 0.26% increased probability of PD occurrence (95% CI: 0.01%, 0.52%; P = 0.04). Diabetes mellitus (DM) had a 1.38 times greater likelihood of developing PD (OR:1.38; 95% CI: 1.004, 1.89; P = 0.046), corresponding to a 0.32% increased probability of PD occurrence (95% CI: -0.03%, 0.67%; P = 0.07). Nevertheless, no correlation was observed between hyperlipidemia, waist circumference and PD. Conclusion: MetS does not affect PD; however, hypertension and DM significantly increase the risk of PD. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
|---|