The effect of hyperlipidemia on overall survival in patients with cancer was differentiated by BMI and hyperlipidemia type.
Background and aims: The impact of lipids on the overall survival (OS) of patients with malignancy has not yet been clarified. This study aimed to evaluate the effect of hyperlipidemia on the OS among Chinese patients based on Body Mass Index (BMI) stratifications and hyperlipidemia types. Method: T...
| Publicado en: | Nutrition & Metabolism Vol. 21; no. 1; pp. 1 - 11 |
|---|---|
| Autores principales: | , , , , , , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
BioMed Central
6/24/2024
|
| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=178065032&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 178065032 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 17437075 1CYX jtl: Nutrition & Metabolism issn: 17437075 maglogo: N pubinfo: dt: 6/24/2024 vid: 21 iid: 1 pid: 24147 pub: BioMed Central artinfo: ui: 178065032 178065032 178065032 10.1186/s12986-024-00811-1 178065032 ppf: 1 ppct: 10 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: The effect of hyperlipidemia on overall survival in patients with cancer was differentiated by BMI and hyperlipidemia type. aug: au: Tian, Hai-Ying Yang, Ming Xie, Hai-Lun Ruan, Guo-Tian Ge, Yi-Zhong Zhang, Xiao-Wei Zhang, He-Yang Liu, Chen-An Liu, Tong Shi, Han-Ping affil: Department of Gastrointestinal Surgery/Department of Clinical Nutrition, Beijing Shijitan Hospital, Capital Medical University, 100038, Beijing, China sug: subj: Hyperlipidemia Blood Overall Survival Evaluation Cancer Patients China Body Mass Index Human China Male Female Middle Age Kaplan-Meier Estimator Log-Rank Test Cox Proportional Hazards Model Confidence Intervals Descriptive Statistics Lipoproteins Blood Cholesterol Blood Triglycerides Blood Funding Source Middle Aged: 45-64 years Male Female ab: Background and aims: The impact of lipids on the overall survival (OS) of patients with malignancy has not yet been clarified. This study aimed to evaluate the effect of hyperlipidemia on the OS among Chinese patients based on Body Mass Index (BMI) stratifications and hyperlipidemia types. Method: The patients in this study were derived from the Investigation of the Nutrition Status and Clinical Outcome of Common Cancers (INSCOC) trial. Kaplan–Meier was used to draw the survival curve, and the log-rank test was used to estimate the survival rates between each group. Cox proportional hazards regression models were used to estimate the hazard ratios (HR) and 95% confidence intervals (CI). Results: A total of 9054 patients were included in the final study, with a median age of 59 years, and 55.3% (5004) of them were males. Regarding types of hyperlipidemia, only low high-density lipoprotein was an independent risk factor for the prognosis of all patients (HR = 1.35, 95% CI: 1.25–1.45, P < 0.001), while high total cholesterol (HR = 1.01, 95% CI: 0.90–1.15, P = 0.839) and high low-density lipoprotein (HR = 1.03, 95%CI: 0.91–1.16, P = 0.680) were not. In terms of BMI stratification, the effect of triglycerides on prognosis varied; high triglycerides were an independent risk factor for the prognosis of underweight patients (HR = 1.56, 95% CI:1.05–2.32, P = 0.027) and a protective factor for overweight patients (HR = 0.75, 95% CI: 0.63–0.89, P = 0.001). However, for normal-weight patients, there was no significant statistical difference (HR = 0.88, 95%CI: 0.75–1.03, P = 0.108). Conclusions: The impact of hyperlipidemia on the OS among patients with cancer varied by different BMI and hyperlipidemia types. BMI and hyperlipidemia type ought to be considered in combination to estimate the prognosis of patients with malignancy. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
|---|