Improving Delivery and Use of HIV Pre-Exposure Prophylaxis in the US: A Systematic Review of Implementation Strategies and Adjunctive Interventions.

Implementation of pre-exposure prophylaxis (PrEP) to prevent HIV transmission is suboptimal in the United States. To date, the literature has focused on identifying determinants of PrEP use, with a lesser focus on developing and testing change methods to improve PrEP implementation. Moreover, the ch...

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Published in:AIDS & Behavior Vol. 28; no. 7; pp. 2321 - 2340
Main Authors: Merle, James L., Benbow, Nanette, Li, Dennis H., Zapata, Juan P., Queiroz, Artur, Zamantakis, Alithia, McKay, Virginia, Keiser, Brennan, Villamar, Juan A., Mustanski, Brian, Smith, Justin D.
Format: research systematic review tables/charts Journal Article
Published: Springer Nature Jul2024
Online Access:View this record in EBSCOhost
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          Merle, James L.
          Benbow, Nanette
          Li, Dennis H.
          Zapata, Juan P.
          Queiroz, Artur
          Zamantakis, Alithia
          McKay, Virginia
          Keiser, Brennan
          Villamar, Juan A.
          Mustanski, Brian
          Smith, Justin D.
        affil: https://ror.org/03r0ha626 Department of Population Health Sciences, Spencer Fox Eccles School of Medicine, University of Utah, Salt Lake City, UT, USA
      sug:
        subj:
          HIV Infections Prevention and Control
          HIV Infections Transmission
          Disease Transmission Prevention and Control
          Pre-Exposure Prophylaxis
          Anti-HIV Agents Administration and Dosage
          Program Implementation
          Quality Improvement
          Health Care Delivery
          Patient Compliance
          Human
          Male
          Female
          United States
          Systematic Review
          Medline
          Psycinfo
          Community Health Services
          Funding Source
          Male
          Female
      ab: Implementation of pre-exposure prophylaxis (PrEP) to prevent HIV transmission is suboptimal in the United States. To date, the literature has focused on identifying determinants of PrEP use, with a lesser focus on developing and testing change methods to improve PrEP implementation. Moreover, the change methods available for improving the uptake and sustained use of PrEP have not been systematically categorized. To summarize the state of the literature, we conducted a systematic review of the implementation strategies used to improve PrEP implementation among delivery systems and providers, as well as the adjunctive interventions used to improve the uptake and persistent adherence to PrEP among patients. Between November 2020 and January 2021, we searched Ovid MEDLINE, PsycINFO, and Web of Science for peer reviewed articles. We identified 44 change methods (18 implementation strategies and 26 adjunctive interventions) across a variety of clinical and community-based service settings. We coded implementation strategies and adjunctive interventions in accordance with established taxonomies and reporting guidelines. Most studies focused on improving patient adherence to PrEP and most conducted pilot trials. Just over one-third of included studies demonstrated a positive effect on outcomes. In order to end the human immunodeficiency virus (HIV) epidemic in the U.S., future, large scale HIV prevention research is needed that develops and evaluates implementation strategies and adjunctive interventions for target populations disproportionately affected by HIV.
      pubtype: Academic Journal
      doctype:
        research
        systematic review
        tables/charts
        Journal Article
      ougenre: Article
    language: English
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