Association of bone fracture with 30-year body mass index (BMI) trajectories: findings from the Framingham Heart Study: Bone fracture and 30-year BMI trajectories.
Summary: A knowledge gap exists in associating later life's osteoporotic fracture and middle adulthood's BMI trajectories. We observed an association showing those transitioning from overweight to normal weight face a higher fracture risk in late adulthood, emphasizing the potential benefits of main...
| Published in: | Osteoporosis International Vol. 35; no. 7; pp. 1205 - 1213 |
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| Main Authors: | , , , , , |
| Format: | research tables/charts Journal Article |
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Springer Nature
Jul2024
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| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=178130748&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 178130748 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 0937941X O4T jtl: Osteoporosis International issn: 0937941X maglogo: N pubinfo: dt: Jul2024 vid: 35 iid: 7 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 178130748 176464006 178130748 178130748 10.1007/s00198-024-07068-7 178130748 ppf: 1205 ppct: 8 formats: tig: atl: Association of bone fracture with 30-year body mass index (BMI) trajectories: findings from the Framingham Heart Study: Bone fracture and 30-year BMI trajectories. aug: au: Xin, Zihao Xu, Hanfei Zhang, Xiaoyu Samelson, Elizabeth J. Kiel, Douglas P. Liu, Ching-Ti affil: https://ror.org/05qwgg493 Department of Biostatistics, Boston University School of Public Health, 801 Massachusetts Ave, Third Floor, 02118, Boston, MA, USA sug: subj: Obesity Body Mass Index Evaluation Body Mass Index Evaluation Osteoporotic Fractures Risk Factors Risk Assessment Human Adult Middle Age Aged Funding Source Prospective Studies Regression Cox Proportional Hazards Model Confidence Intervals Descriptive Statistics Body Weight Adult: 19-44 years Middle Aged: 45-64 years Aged: 65+ years ab: Summary: A knowledge gap exists in associating later life's osteoporotic fracture and middle adulthood's BMI trajectories. We observed an association showing those transitioning from overweight to normal weight face a higher fracture risk in late adulthood, emphasizing the potential benefits of maintaining a stable BMI to reduce late-life fractures. Purpose: Numerous studies on the relationship between obesity and fractures have relied on body mass index (BMI) at a single time point, yielding inconclusive results. This study investigated the association of BMI trajectories over middle adulthood with fracture risk in late adulthood. Methods: This prospective cohort study analyzed 1772 qualified participants from the Framingham Original Cohort Study, with 292 (16.5%) incident fractures during an average of 17.1-year follow-up. We constructed BMI trajectories of age 35–64 years based on latent class mixed modeling and explored their association with the risk of fracture after 65 years using the Cox regression. Results: The result showed that compared to the BMI trajectory Group 4 (normal to slightly overweight; see "Methods" for detailed description), Group 1 (overweight declined to normal weight) had a higher all-fracture risk after age 65 (hazard ratio [HR], 2.22, 95% CI, 1.13–4.39). The secondary analysis focusing on lower extremity fractures (pelvis, hip, leg, and foot) showed a similar association pattern. Conclusions: This study suggested that people whose BMI slightly increased from normal weight to low-level overweight during 30 years of middle adulthood confer a significantly lower risk of fracture in later life than those whose BMI declined from overweight to normal weight. This result implies the potentially beneficial effects of avoiding weight loss to normal weight during middle adulthood for overweight persons, with reduced fracture risk in late life. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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