Noninvasive diagnosis of liver cirrhosis: qualitative and quantitative imaging biomarkers.
A diagnosis of cirrhosis initiates a shift in the management of chronic liver disease and affects the diagnostic workflow and treatment decision of primary liver cancer. Liver biopsy remains the gold standard for cirrhosis diagnosis, but it is invasive and susceptible to sampling bias and observer v...
| Publicado en: | Abdominal Radiology Vol. 49; no. 6; pp. 2098 - 2116 |
|---|---|
| Autores principales: | , , , , , , |
| Formato: | Journal Article |
| Publicado: |
Springer Nature
Jun2024
|
| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=178150399&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 178150399 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 2366004X JT14 jtl: Abdominal Radiology issn: 2366004X maglogo: N pubinfo: dt: Jun2024 vid: 49 iid: 6 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 178150399 175517371 10.1007/s00261-024-04225-8 178150399 ppf: 2098 ppct: 18 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Noninvasive diagnosis of liver cirrhosis: qualitative and quantitative imaging biomarkers. aug: au: Zheng, Tianying Qu, Yali Chen, Jie Yang, Jie Yan, Hualin Jiang, Hanyu Song, Bin affil: https://ror.org/011ashp19 Department of Radiology, West China Hospital, Sichuan University, No. 37 Guoxue Alley, 610041, Chengdu, Sichuan, China sug: ab: A diagnosis of cirrhosis initiates a shift in the management of chronic liver disease and affects the diagnostic workflow and treatment decision of primary liver cancer. Liver biopsy remains the gold standard for cirrhosis diagnosis, but it is invasive and susceptible to sampling bias and observer variability. Various qualitative and quantitative imaging biomarkers based on ultrasound, CT and MRI have been proposed for noninvasive diagnosis of cirrhosis. Qualitative imaging features are easy to apply but have moderate diagnostic sensitivity. Elastography techniques allow quantitative assessment of liver stiffness and are highly accurate for cirrhosis diagnosis. Ultrasound elastography are widely used in clinical practice, while MR elastography has narrower availability. Although not applicable in clinical practice yet, other quantitative imaging features, including liver surface nodularity, linear and volumetric measurement, extracellular volume fraction, liver enhancement on hepatobiliary phase, and parameters derived from diffusion-weighted imaging, can provide additional information of liver morphology, perfusion, and function, thus may increase diagnosis performance. The introduction of radiomics and deep learning has further improved diagnostic accuracy while reducing subjectivity. Several imaging features may also help to assess liver function and outcomes in patients with cirrhosis. In this review, we summarize the qualitative and quantitative imaging biomarkers for noninvasive cirrhosis diagnosis, and the assessment of liver function and outcomes, and discuss the challenges and future directions in this field. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
|---|