Combining T1rho and advanced diffusion MRI for noninvasively staging liver fibrosis: an experimental study in rats.
Purpose: To investigate the value of imaging parameters derived from T1 relaxation times in the rotating frame (T1ρ or T1rho), diffusion kurtosis imaging (DKI) and intravoxel incoherent motion (IVIM) in assessment of liver fibrosis in rats and propose an optimal diagnostic model based on multiparame...
| Publicado en: | Abdominal Radiology Vol. 49; no. 6; pp. 1881 - 1892 |
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| Autores principales: | , , , , , , , |
| Formato: | Journal Article |
| Publicado: |
Springer Nature
Jun2024
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=178150415&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 178150415 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 2366004X JT14 jtl: Abdominal Radiology issn: 2366004X maglogo: N pubinfo: dt: Jun2024 vid: 49 iid: 6 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 178150415 176528787 10.1007/s00261-024-04327-3 178150415 ppf: 1881 ppct: 11 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Combining T1rho and advanced diffusion MRI for noninvasively staging liver fibrosis: an experimental study in rats. aug: au: Guo, Yiwan Guo, Tingting Huang, Chen Sun, Peng Wu, Zhigang Jin, Ziwei Zheng, Chuansheng Li, Xin affil: Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 430022, Wuhan, China sug: ab: Purpose: To investigate the value of imaging parameters derived from T1 relaxation times in the rotating frame (T1ρ or T1rho), diffusion kurtosis imaging (DKI) and intravoxel incoherent motion (IVIM) in assessment of liver fibrosis in rats and propose an optimal diagnostic model based on multiparametric MRI. Methods: Thirty rats were divided into one control group and four fibrosis experimental groups (n = 6 for each group). Liver fibrosis was induced by administering thioacetamide (TAA) for 2, 4, 6, and 8 weeks. T1ρ, mean kurtosis (MK), mean diffusivity (MD), perfusion fraction (f), true diffusion coefficient (D), and pseudo-diffusion coefficient (D*) were measured and compared among different fibrosis stages. An optimal diagnostic model was established and the diagnostic efficiency was evaluated by receiver operating characteristic (ROC) curve analysis. Results: The mean AUC values, sensitivity, and specificity of T1ρ and MD derived from DKI across all liver fibrosis stages were comparable but much higher than those of other imaging parameters (0.954, 92.46, 91.85 for T1ρ; 0.949, 92.52, 91.24 for MD). The model combining T1ρ and MD exhibited better diagnostic performance with higher AUC values than any individual method for staging liver fibrosis (≥ F1: 1.000 (0.884–1.000); ≥ F2: 0.935 (0.782–0.992); ≥ F3: 0.982 (0.852–1.000); F4: 0.986 (0.859–1.000)). Conclusion: Among the evaluated imaging parameters, T1ρ and MD were superior for differentiating varying liver fibrosis stages. The model combining T1ρ and MD was promising to be a credible diagnostic biomarker to detect and accurately stage liver fibrosis. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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