Clinical Characteristics and Outcomes of Polyarteritis Nodosa: An International Study.
Objective: We describe the demographics, clinical features, disease course, and survival of polyarteritis nodosa (PAN) through an international collaboration (GLOBAL‐PAN). Methods: Patients with PAN were recruited between 1990 and 2020 from observational cohorts of nine countries across Europe, Japa...
| Publicado en: | Arthritis & Rheumatology Vol. 76; no. 7; pp. 1120 - 1130 |
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| Autores principales: | , , , , , , , , , , , , , , , , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Wiley-Blackwell
Jul2024
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=178161899&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 178161899 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 23265191 H06R jtl: Arthritis & Rheumatology issn: 23265191 maglogo: N pubinfo: dt: Jul2024 vid: 76 iid: 7 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 178161899 175564706 178161899 178161899 10.1002/art.42817 178161899 ppf: 1120 ppct: 10 formats: tig: atl: Clinical Characteristics and Outcomes of Polyarteritis Nodosa: An International Study. aug: au: Karadag, Omer Bolek, Ertugrul Cagri Ayan, Gizem Mohammad, Aladdin J. Grayson, Peter C. Pagnoux, Christian Martín‐Nares, Eduardo Monti, Sara Abe, Yoshiyuki Alberici, Federico Alibaz‐Oner, Fatma Cuthbertson, David Dagna, Lorenzo Direskeneli, Haner Khalidi, Nader A. Koening, Curry Langford, Carol A. McAlear, Carol A. Monach, Paul A. Moroni, Luca affil: Hacettepe University, Ankara, Turkey sug: subj: Polyarteritis Nodosa World Health Sociodemographic Factors Survival Rate Evaluation Disease Attributes Collaboration Human Prospective Studies Nonexperimental Studies Descriptive Statistics Male Female Adult Middle Age Proteinuria Gastrointestinal Diseases Age Factors Creatinine Blood Central Nervous System Retrospective Design Record Review Funding Source Adult: 19-44 years Middle Aged: 45-64 years Male Female ab: Objective: We describe the demographics, clinical features, disease course, and survival of polyarteritis nodosa (PAN) through an international collaboration (GLOBAL‐PAN). Methods: Patients with PAN were recruited between 1990 and 2020 from observational cohorts of nine countries across Europe, Japan, and North America. Eligibility was retrospectively defined using the European Medicines Agency classification algorithm. Patients with PAN related to hepatitis B virus (n = 12) and two monogenic diseases mimicking PAN, deficiency of adenosine deaminase 2 enzyme (n = 16) or familial Mediterranean fever (n = 11), were excluded. Data regarding organ involvement, relapse, disease‐related damage, and survival were analyzed. Results: Three hundred fifty‐eight patients (female:male ratio 174:184), including those with systemic PAN (sPAN, n = 282) and cutaneous PAN (n = 76), were included. Twenty‐five were pediatric onset. Mean ± SD age at diagnosis was 44.3 ± 18.1 years. Constitutional symptoms (71.5%), cutaneous involvement (70.5%), musculoskeletal findings (69.1%), and neurologic features (48.0%) were common manifestations. Among patients with sPAN, gastrointestinal involvement and proteinuria over 400 mg/day were reported in 52.2% and 11.2%, respectively. During a median (interquartile range) 59.6 (99.5) months of follow‐up, relapse occurred in 48.5% of patients. One, 5‐ and 10‐year survival rates for sPAN were 97.1%, 94.0%, and 89.0%, respectively. Predictors of death for sPAN included age ≥65 years at diagnosis, serum creatinine at diagnosis >140 μmol/L, gastrointestinal manifestations, and central nervous system (CNS) involvement. Conclusion: The spectrum of PAN remains a complex, multifaceted disease. Relapse is common. Age ≥65 years and serum creatinine >140 μmol/L at diagnosis, as well as gastrointestinal and CNS involvement, are independent predictors of death in sPAN. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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