The Lipidomic Profile Is Associated with the Dietary Pattern in Subjects with and without Diabetes Mellitus from a Mediterranean Area.
Lipid functions can be influenced by genetics, age, disease states, and lifestyle factors, particularly dietary patterns, which are crucial in diabetes management. Lipidomics is an expanding field involving the comprehensive exploration of lipids from biological samples. In this cross-sectional stud...
| Publicado en: | Nutrients Vol. 16; no. 12; pp. 1805 - 1820 |
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| Autores principales: | , , , , , , , , , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
MDPI
Jun2024
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=178191409&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 178191409 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 20726643 B0TT jtl: Nutrients issn: 20726643 maglogo: N pubinfo: dt: Jun2024 vid: 16 iid: 12 pid: 97109 pub: MDPI artinfo: ui: 178191409 178191409 178191409 10.3390/nu16121805 178191409 ppf: 1805 ppct: 15 formats: tig: atl: The Lipidomic Profile Is Associated with the Dietary Pattern in Subjects with and without Diabetes Mellitus from a Mediterranean Area. aug: au: Rojo-López, Marina Idalia Barranco-Altirriba, Maria Rossell, Joana Antentas, Maria Castelblanco, Esmeralda Yanes, Oscar Weber, Ralf J. M. Lloyd, Gavin R. Winder, Catherine Dunn, Warwick B. Julve, Josep Granado-Casas, Minerva Mauricio, Dídac affil: Institut de Recerca Sant Pau (IR SANT PAU), Sant Quintí 77-79, 08041 Barcelona, Spain sug: subj: Diabetes Mellitus, Type 1 Diabetes Mellitus, Type 2 Lipids Blood Nutritional Assessment Dietary Patterns Metabolomics Human Cross Sectional Studies Mediterranean Region Diabetic Patients Questionnaires Liquid Chromatography-Mass Spectrometry Multiple Linear Regression Triglycerides Food Habits Dietary Carbohydrates Dietary Fats Dietary Proteins Scales Eating Behavior Mediterranean Diet Adult Middle Age Aged Male Female Carnitine Spain Funding Source Phosphatidylcholines Blood Adult: 19-44 years Middle Aged: 45-64 years Aged: 65+ years Male Female ab: Lipid functions can be influenced by genetics, age, disease states, and lifestyle factors, particularly dietary patterns, which are crucial in diabetes management. Lipidomics is an expanding field involving the comprehensive exploration of lipids from biological samples. In this cross-sectional study, 396 participants from a Mediterranean region, including individuals with type 1 diabetes (T1D), type 2 diabetes (T2D), and non-diabetic individuals, underwent lipidomic profiling and dietary assessment. Participants completed validated food frequency questionnaires, and lipid analysis was conducted using ultra-high-performance liquid chromatography coupled with mass spectrometry (UHPLC/MS). Multiple linear regression models were used to determine the association between lipid features and dietary patterns. Across all subjects, acylcarnitines (AcCa) and triglycerides (TG) displayed negative associations with the alternate Healthy Eating Index (aHEI), indicating a link between lipidomic profiles and dietary habits. Various lipid species (LS) showed positive and negative associations with dietary carbohydrates, fats, and proteins. Notably, in the interaction analysis between diabetes and the aHEI, we found some lysophosphatidylcholines (LPC) that showed a similar direction with respect to aHEI in non-diabetic individuals and T2D subjects, while an opposite direction was observed in T1D subjects. The study highlights the significant association between lipidomic profiles and dietary habits in people with and without diabetes, particularly emphasizing the role of healthy dietary choices, as reflected by the aHEI, in modulating lipid concentrations. These findings underscore the importance of dietary interventions to improve metabolic health outcomes, especially in the context of diabetes management. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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