Palpitations in Women With Breast Cancer Are Associated With Polymorphisms for Neurotransmitter Genes.
OBJECTIVES: To evaluate for associations between the occurrence of palpitations reported by women prior to breast cancer surgery and single nucleotide polymorphisms (SNPs) for neurotransmitter genes. SAMPLE & SETTING: A total of 398 women, who were scheduled for unilateral breast cancer surgery, pro...
| Publicado en: | Oncology Nursing Forum Vol. 51; no. 4; pp. 332 - 349 |
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| Autores principales: | , , , , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Oncology Nursing Society
Jul2024
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=178196779&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 178196779 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 0190535X 4F0 jtl: Oncology Nursing Forum issn: 0190535X maglogo: N pubinfo: dt: Jul2024 vid: 51 iid: 4 pid: 12496 pub: Oncology Nursing Society place: Pittsburgh, Pennsylvania artinfo: ui: 178196779 178196779 178196779 10.1188/24.ONF.332-348 178196779 ppf: 332 ppct: 17 formats: fmt: @attributes: type: P tig: atl: Palpitations in Women With Breast Cancer Are Associated With Polymorphisms for Neurotransmitter Genes. aug: au: Ying Sheng Conley, Yvette P. Paul, Steven M. Cooper, Bruce A. Carpenter, Janet S. Hammer, Marilyn J. Levine, Jon D. Miaskowski, Christine affil: Assistant professor in the School of Nursing at Vanderbilt University in Nashville, TN. sug: subj: Heart Rate Variability Breast Neoplasms Surgery Polymorphism, Single Nucleotide Polymorphism, Genetic Neurotransmitters Gene Expression Women's Health Human Female Blood Specimen Collection Breast Neoplasms Diagnosis Genomics Logistic Regression Haplotypes Receptors, Serotonin Dopamine Receptors, Adrenergic GABA Prospective Studies Karnofsky Performance Status Questionnaires Scales Genotype Chi Square Test Fisher's Exact Test Confidence Intervals Self Report Regression Funding Source Female ab: OBJECTIVES: To evaluate for associations between the occurrence of palpitations reported by women prior to breast cancer surgery and single nucleotide polymorphisms (SNPs) for neurotransmitter genes. SAMPLE & SETTING: A total of 398 women, who were scheduled for unilateral breast cancer surgery, provided detailed information on demographic and clinical characteristics and the occurrence of palpitations prior to breast cancer surgery. METHODS & VARIABLES: The occurrence of palpitations was assessed using a single item (i.e., "heart races/pounds" in the past week ["yes"/"no"]). Blood samples were collected for genomic analyses. Multiple logistic regression analyses were used to identify associations between the occurrence of palpitations and variations in neurotransmitter genes. RESULTS: Nine SNPs and two haplotypes among 11 candidate genes were associated with the occurrence of palpitations. These genes encode for a number of neurotransmitters and/or their receptors, including serotonin, norepinephrine, dopamine, gammaamino butyric acid, Substance P, and neurokinin. IMPLICATIONS FOR NURSING: These findings suggest that alterations in a variety of neurotransmitters contribute to the development of this symptom. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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