Fatal Infections Differentially Involve Allograft and Native Lungs in Single Lung Transplant Recipients.
Context.--Respiratory infections complicate lung transplantation and increase the risk of allograft dysfunction. Allograft lungs may have different susceptibilities to infection than native lungs, potentially leading to different disease severity in lungs of single lung transplant recipients (SLTRs)...
| Publicado en: | Archives of Pathology & Laboratory Medicine Vol. 148; no. 7; pp. 784 - 797 |
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| Autores principales: | , , , , , , , , |
| Formato: | diagnostic images pictorial research tables/charts Journal Article |
| Publicado: |
College of American Pathologists
Jul2024
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=178199647&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 178199647 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00039985 1FS jtl: Archives of Pathology & Laboratory Medicine issn: 00039985 maglogo: N pubinfo: dt: Jul2024 vid: 148 iid: 7 pid: 2550 pub: College of American Pathologists place: Northfield, Illinois artinfo: ui: 178199647 178199647 178199647 10.5858/arpa.2023-0227-OA 178199647 ppf: 784 ppct: 13 formats: fmt: @attributes: type: P tig: atl: Fatal Infections Differentially Involve Allograft and Native Lungs in Single Lung Transplant Recipients. aug: au: Villalba, Julian A. Cheek-Norgan, Heidi Johnson, Tucker F. Yi, Eunhee S. Boland, Jennifer M. Aubry, Marie-Christine Pennington, Kelly M. Scott, John P. Roden, Anja C. affil: Departments of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota sug: subj: Lung Transplantation Transplant Recipients Respiratory Tract Infections Mortality Fatal Outcome Allografts Lung Pathology Respiratory Tract Infections Pathology Human Male Female Adult Middle Age Aged Record Review Tomography, X-Ray Computed Radiography, Thoracic Histological Techniques Comparative Studies Descriptive Statistics Lung Radiography Retrospective Design Lung Microbiology Respiratory Tract Infections Risk Factors Adult: 19-44 years Middle Aged: 45-64 years Aged: 65+ years Male Female ab: Context.--Respiratory infections complicate lung transplantation and increase the risk of allograft dysfunction. Allograft lungs may have different susceptibilities to infection than native lungs, potentially leading to different disease severity in lungs of single lung transplant recipients (SLTRs). Objective.--To study whether infections affect allograft and native lungs differently in SLTRs but similarly in double LTRs (DLTRs). Design.--Using an institutional database of LTRs, medical records were searched, chest computed tomography studies were systematically reviewed, and histopathologic features were recorded per lung lobe and graded semiquantitatively. A multilobar-histopathology score (MLHS) including histopathologic data from each lung and a bilateral ratio (MLHSratio) comparing histopathologies between both lungs were calculated in SLTRs and compared to DLTRs. Results.--Six SLTRs died of infection involving the lungs. All allografts showed multifocal histopathologic evidence of infection, but at least 1 lobe of the native lung was uninvolved. In 4 of 5 DLTRs, histopathologic evidence of infection was seen in all lung lobes. On computed tomography, multifocal ground-glass and/or nodular opacities were found in a bilateral distribution in all DLTRs but in only 2 of 6 SLTRs. In SLTRs, the MLHSAllograft was higher than MLHSNative (P ¼ .02). The MLHSratio values of SLTR and DLTR were significantly different (P, .001). Conclusions.--Allograft and native lungs appear to harbor different susceptibilities to infections. The results are important for the management of LTRs. pubtype: Academic Journal doctype: diagnostic images pictorial research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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