Developments in the Design, Conduct, and Reporting of Child Health Trials.
To identify priority areas to improve the design, conduct, and reporting of pediatric clinical trials, the international expert network, Standards for Research (StaR) in Child Health, was assembled and published the first 6 Standards in Pediatrics in 2012. After a recent review summarizing the 247 p...
| Publicado en: | Pediatrics Vol. 154; no. 1; pp. 1 - 14 |
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| Autores principales: | , , , , , , , , , , , , , , , |
| Formato: | review tables/charts Journal Article |
| Publicado: |
American Academy of Pediatrics
Jul2024
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=178262844&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 178262844 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00314005 PDT jtl: Pediatrics issn: 00314005 maglogo: N pubinfo: dt: Jul2024 vid: 154 iid: 1 pid: 1659 pub: American Academy of Pediatrics place: Elk Grove Village, Illinois artinfo: ui: 178262844 178262844 178262844 10.1542/peds.2024-065799 178262844 ppf: 1 ppct: 13 formats: tig: atl: Developments in the Design, Conduct, and Reporting of Child Health Trials. aug: au: Baba, Ami Aregbesola, Alex Caldwell, Patrina H. Y. Elliott, Sarah A. Elsman, Ellen B. M. Fernandes, Ricardo M. Hartling, Lisa Heath, Anna Kelly, Lauren E. Preston, Jennifer Sammy, Adrian Webbe, James Williams, Katrina Woolfall, Kerry Klassen, Terry P. Offringa, Martin affil: Child Health Evaluative Sciences, The Hospital for Sick Children Research Institute, Toronto, Ontario, Canada sug: subj: Child Health Pediatrics Standards Study Design Standards Clinical Trials Research, Medical Implementation Science Outcome Assessment Age Factors ab: To identify priority areas to improve the design, conduct, and reporting of pediatric clinical trials, the international expert network, Standards for Research (StaR) in Child Health, was assembled and published the first 6 Standards in Pediatrics in 2012. After a recent review summarizing the 247 publications by StaR Child Health authors that highlight research practices that add value and reduce research "waste," the current review assesses the progress in key child health trial methods areas: consent and recruitment, containing risk of bias, roles of data monitoring committees, appropriate sample size calculations, outcome selection and measurement, and age groups for pediatric trials. Although meaningful change has occurred within the child health research ecosystem, measurable progress is still disappointingly slow. In this context, we identify and review emerging trends that will advance the agenda of increased clinical usefulness of pediatric trials, including patient and public engagement, Bayesian statistical approaches, adaptive designs, and platform trials. We explore how implementation science approaches could be applied to effect measurable improvements in the design, conducted, and reporting of child health research. pubtype: Academic Journal doctype: review tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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