Long-lasting improvements in episodic memory among subjects with mild cognitive impairment who received transcranial direct current stimulation combined with cognitive treatment and telerehabilitation: a multicentre, randomized, active-controlled study.
Background: In recent years, an increasing number of studies have examined the potential efficacy of cognitive training procedures in individuals with normal ageing and mild cognitive impairment (MCI). Objective: The aims of this study were to (i) evaluate the efficacy of the cognitive Virtual Reali...
| Publicado en: | Frontiers in Aging Neuroscience pp. 1 - 22 |
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| Autores principales: | , , , , , , , , , , , , , , , , , |
| Formato: | pictorial research tables/charts randomized controlled trial Journal Article |
| Publicado: |
Frontiers Media S.A.
2024
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=178268311&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 178268311 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 16634365 BG2U jtl: Frontiers in Aging Neuroscience issn: 16634365 maglogo: N pubinfo: dt: 2024 pid: 40038 pub: Frontiers Media S.A. artinfo: ui: 178268311 178268311 178268311 10.3389/fnagi.2024.1414593 178268311 ppf: 1 ppct: 21 formats: tig: atl: Long-lasting improvements in episodic memory among subjects with mild cognitive impairment who received transcranial direct current stimulation combined with cognitive treatment and telerehabilitation: a multicentre, randomized, active-controlled study. aug: au: Manenti, Rosa Baglio, Francesca Pagnoni, Ilaria Gobbi, Elena Campana, Elena Alaimo, Cristina Rossetto, Federica Di Tella, Sonia Pagliari, Chiara Geviti, Andrea Bonfiglio, Natale Salvatore Calabrò, Rocco Salvatore Cimino, Vincenzo Binetti, Giuliano Quartarone, Angelo Bramanti, Placido Cappa, Stefano F. Cotelli, Paolo Maria Rossini Maria affil: Neuropsychology Unit, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, Brescia, Italy sug: subj: Mild Cognitive Impairment Therapy Cognitive Therapy Telerehabilitation Episodic Memory Prefrontal Cortex Treatment Outcomes Combined Modality Therapy Human Randomized Controlled Trials Random Assignment Multicenter Studies Geriatric Depression Scale Scales Questionnaires Neuropsychological Tests Language Tests Executive Function Cognition Attention Home Health Care Male Female Aged Aged, 80 and Over Analysis of Variance Kruskal-Wallis Test Chi Square Test Italy Funding Source Aged: 65+ years Aged, 80 & over Male Female ab: Background: In recent years, an increasing number of studies have examined the potential efficacy of cognitive training procedures in individuals with normal ageing and mild cognitive impairment (MCI). Objective: The aims of this study were to (i) evaluate the efficacy of the cognitive Virtual Reality Rehabilitation System (VRRS) combined with anodal transcranial direct current stimulation (tDCS) applied to the left dorsolateral prefrontal cortex compared to placebo tDCS stimulation combined with VRRS and (ii) to determine how to prolong the beneficial effects of the treatment. A total of 109 subjects with MCI were assigned to 1 of 5 study groups in a randomized controlled trial design: (a) face-to-face (FTF) VRRS during anodal tDCS followed by cognitive telerehabilitation (TR) (clinic-atDCS-VRRS+Tele@H-VRRS); (b) FTF VRRS during placebo tDCS followed by TR (clinic-ptDCS-VRRS+Tele@H-VRRS); (c) FTF VRRS followed by cognitive TR (clinic-VRRS+Tele@H-VRRS); (d) FTF VRRS followed by at-home unstructured cognitive stimulation (clinic-VRRS+@H-UCS); and (e) FTF cognitive treatment as usual (clinic-TAU). Results: An improvement in episodic memory was observed after the end of clinic-atDCS-VRRS (p < 0.001). We found no enhancement in episodic memory after clinic-ptDCS-VRRS or after clinic-TAU. Moreover, the combined treatment led to prolonged beneficial effects (clinicatDCS- VRRS+Tele@H-VRRS vs. clinic-ptDCS-VRRS+Tele@H-VRRS: p = 0.047; clinic-atDCS-VRRS+Tele@H-VRRS vs. clinic-VRRS+Tele@H-VRRS: p = 0.06). Discussion: The present study provides preliminary evidence supporting the use of individualized VRRS combined with anodal tDCS and cognitive telerehabilitation for cognitive rehabilitation. pubtype: Academic Journal doctype: pictorial research tables/charts randomized controlled trial Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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