Perinatal outcomes of synthetic cathinone ("bath salts") use in pregnancy: a case series.

Little is known about the effects of exposure to synthetic cathinone drugs in pregnancy. We report five cases of pregnant women with opioid use disorder who tested positive for α-Pyrrolidinohexiophenone (alpha-PHP), a synthetic cathinone. We describe key characteristics of the course of disease and...

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Publicado en:Journal of Substance Use Vol. 29; no. 4; pp. 524 - 528
Autores principales: Frew, Julia R., Goodman, Daisy, Brunette, Mary
Formato: case study tables/charts Journal Article
Publicado: Taylor & Francis Ltd Aug2024
Acceso en línea:Ver este registro en EBSCOhost
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      dt: Aug2024
      vid: 29
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      pub: Taylor & Francis Ltd
      place: Philadelphia, Pennsylvania
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        10.1080/14659891.2023.2183151
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        atl: Perinatal outcomes of synthetic cathinone ("bath salts") use in pregnancy: a case series.
      aug:
        au:
          Frew, Julia R.
          Goodman, Daisy
          Brunette, Mary
        affil: Dartmouth Geisel School of Medicine and Dartmouth-Hitchcock Medical Center, One Medical Center Drive, Lebanon, New Hampshire
      sug:
        subj:
          Synthetic Cathinone Adverse Effects
          Pregnancy Outcomes
          Pregnancy Complications Risk Factors
          Human
          Female
          Adult
          Expectant Mothers
          Substance Use Disorders
          Central Nervous System Stimulants
          Gestational Age
          Foster Home Care
          Pregnancy
          Urinalysis
          Poverty
          Maternal Exposure
          Pregnancy-Induced Hypertension Risk Factors
          Infant, Premature
          Infant, Newborn
          Adult: 19-44 years
          Infant, Newborn: birth-1 month
          Female
      ab: Little is known about the effects of exposure to synthetic cathinone drugs in pregnancy. We report five cases of pregnant women with opioid use disorder who tested positive for α-Pyrrolidinohexiophenone (alpha-PHP), a synthetic cathinone. We describe key characteristics of the course of disease and its treatment, as well as perinatal and treatment outcomes. We present a composite case example demonstrating relevant clinical issues. All cases of women with synthetic cathinone use were notable for decreased engagement in care and clinical signs associated with active substance use (difficulty maintaining personal hygiene, disorganized behavior suggestive of psychostimulant intoxication) despite reporting abstinence and testing negative for psychostimulants on standard urine toxicology testing. Four of the five women delivered prior to 38 weeks' gestation and infants of three of the mothers were placed in foster care at birth. It is not known to what degree synthetic cathinone use may have contributed to these adverse perinatal outcomes in these cases. Research on the effects and treatment of synthetic cathinones during pregnancy is needed to guide identification and treatment for women using these substances and to improve outcomes for mothers and infants.
      pubtype: Academic Journal
      doctype:
        case study
        tables/charts
        Journal Article
      ougenre: Article
    language: English
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