Long-term exposure to PM2.5 compositions and O3 and their interactive effects on DNA methylation of peripheral brain-derived neurotrophic factor promoter.
This study examined the associations of long-term exposure to ambient fine particulate matter (PM2.5) compositions/ozone with methylation of peripheral brain-derived neurotrophic factor (BDNF) promoters. A total of 101 participants were recruited from a cohort in Shijiazhuang, Hebei province, China....
| Publicado en: | International Journal of Environmental Health Research Vol. 34; no. 8; pp. 2957 - 2969 |
|---|---|
| Autores principales: | , , , , , , , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Taylor & Francis Ltd
Aug2024
|
| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=178337031&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 178337031 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 09603123 57L jtl: International Journal of Environmental Health Research issn: 09603123 maglogo: Y pubinfo: dt: Aug2024 vid: 34 iid: 8 pid: 377 pub: Taylor & Francis Ltd place: Philadelphia, Pennsylvania artinfo: ui: 178337031 173483406 178337031 178337031 10.1080/09603123.2023.2280157 178337031 ppf: 2957 ppct: 12 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Long-term exposure to PM2.5 compositions and O3 and their interactive effects on DNA methylation of peripheral brain-derived neurotrophic factor promoter. aug: au: Huang, Haoyu Xie, Bing Liu, Yuewei Dong, Guang-Hui Liu, Ruqing Gui, Zhaohuan Chen, Lijun Li, Shanshan Guo, Yuming Yang, Lei Chen, Gongbo affil: Department of Occupational and Environmental Health, School of Public Health, Sun Yat-sen University, Guangzhou, China sug: subj: Particulate Matter Analysis Ozone Analysis DNA Methylation Brain-Derived Neurotrophic Factor Human China Female Male Middle Age Aged Prospective Studies Surveys Polymerase Chain Reaction Sequence Analysis Random Sample Environmental Exposure Sulfates Regression Confidence Intervals Descriptive Statistics Funding Source Middle Aged: 45-64 years Aged: 65+ years Female Male ab: This study examined the associations of long-term exposure to ambient fine particulate matter (PM2.5) compositions/ozone with methylation of peripheral brain-derived neurotrophic factor (BDNF) promoters. A total of 101 participants were recruited from a cohort in Shijiazhuang, Hebei province, China. They underwent baseline and follow-up surveys in 2011 and 2015. DNA methylation levels were detected by bisulfite-PCR amplification and pyrosequencing. Participants' three-year average levels of PM2.5 compositions and ozone were estimated. Bayesian kernel machine regression (BKMR) models were used to examine the joint effects of pollutants on methylation levels. Exposure to PM2.5 compositions and ozone mixtures at the 75th percentile was associated with increased methylation levels at CpG2 of BDNF promoter (203%, 95% CI: 89, 316) than the lowest level of exposure, and sulfate dominated the effect in the BKMR models.Our findings provide clues to the epigenetic mechanisms for the associations of PM2.5 compositions and ozone with BDNF. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
|---|