Serum Vitamin D, Mania and Depression-Related Scores: A Comparison among Mixed Bipolar, Mania, and Healthy Subjects.
Objective: Manic and mixed episodes of bipolar disorder are important episodes of this disorder. The aim of the current study was to assess serum vitamin D (SVD) levels in patients with mania and mixed bipolar disorder, compared to healthy subjects. Method: The current cross-sectional study was cond...
| Published in: | Iranian Journal of Psychiatry Vol. 19; no. 3; pp. 265 - 274 |
|---|---|
| Main Authors: | , , |
| Format: | research tables/charts Journal Article |
| Published: |
Tehran University of Medical Sciences
Jul2024
|
| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=178368886&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 178368886 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 17354587 54ZN jtl: Iranian Journal of Psychiatry issn: 17354587 maglogo: N pubinfo: dt: Jul2024 vid: 19 iid: 3 pid: 21783 pub: Tehran University of Medical Sciences artinfo: ui: 178368886 178368886 178368886 10.18502/ijps.v19i3.15803 178368886 ppf: 265 ppct: 9 formats: tig: atl: Serum Vitamin D, Mania and Depression-Related Scores: A Comparison among Mixed Bipolar, Mania, and Healthy Subjects. aug: au: Astaneh, Ali Nazeri Jafari, Neda Sadighi, Gita affil: Psychosis Research Center, University of Social Welfare and Rehabilitation Sciences, Tehran, Iran. sug: subj: Mania Bipolar Disorder Depression Vitamin D Blood Sex Factors Disease Duration Human Male Female Adult Middle Age Cross Sectional Studies Comparative Studies Hamilton Rating Scale for Depression Scales Severity of Illness Evaluation Analysis of Variance T-Tests Pearson's Correlation Coefficient Chi Square Test Statistical Significance Data Analysis Software Descriptive Statistics Adult: 19-44 years Middle Aged: 45-64 years Male Female ab: Objective: Manic and mixed episodes of bipolar disorder are important episodes of this disorder. The aim of the current study was to assess serum vitamin D (SVD) levels in patients with mania and mixed bipolar disorder, compared to healthy subjects. Method: The current cross-sectional study was conducted on 75 subjects, including healthy subjects (n = 25), patients with acute-phase mania (n = 25), and patients with mixed bipolar disorder (n = 25). The SVD levels were measured in all of the enrolled subjects. The Hamilton Depression Rating Scale (HDRS), Young Mania Rating Scale (YMRS), and Clinical Global Impression- Severity (CGI-S) were used to assess disease activity in patient groups. Data analysis was performed using SPSS version 18. For statistical analysis, analysis of variance (ANOVA), independent-sample t test, Pearson correlation, and Chi-square tests were utilized. P-values < 0.05 were considered statistically significant. Results: The results showed that the mean of SVD was significantly lower in mania and mixed bipolar patients compared to healthy subjects (P < 0.05). In addition, the number of subjects with SVD ≥ 20 ng/ml was higher in the healthy group compared to the patient groups (P < 0.05). Also, SVD was negatively correlated with the CGI-S (r = -0.311; P = 0.028), YMRS (r = -0.464; P = 0.001), and HDRS (r = -0.393; P = 0.005) in the total patient subjects. Conclusion: Prevalence of low SVD was considerably high in mania and mixed bipolar patients compared to healthy subjects. Additionally, meaningful negative correlations were found between SVD and disease activity-related variables including the HDRS, YMRS, and CGI-S. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
|---|