Cover Image
QR Code

Dietary patterns and hepatocellular carcinoma risk: a systematic review and meta-analysis of cohort and case–control studies.

Background: Globally, HCC presents a significant health burden, characterized by high incidence and mortality rates. Epidemiological studies have increasingly suggested a link between dietary patterns and the risk of hepatocellular carcinoma (HCC), yet consensus on this relationship remains elusive....

Full description

Published in:Nutrition & Metabolism Vol. 21; no. 1; pp. 1 - 18
Main Authors: Shu, Wenxi, Liu, Ling, Jiang, Jiaojiao, Yao, Qinghua
Format: meta analysis research systematic review tables/charts Journal Article
Published: BioMed Central 7/11/2024
Online Access:View this record in EBSCOhost
fields @attributes:
  recordID: 1
pdfLink:
plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=178402307&site=ehost-live
header:
  @attributes:
    shortDbName: ccm
    uiTerm: 178402307
    longDbName: CINAHL Complete
    uiTag: AN
  controlInfo:
    bkinfo:
    dissinfo:
    jinfo:
      jid:
        17437075
        1CYX
      jtl: Nutrition & Metabolism
      issn: 17437075
      maglogo: N
    pubinfo:
      dt: 7/11/2024
      vid: 21
      iid: 1
      pid: 24147
      pub: BioMed Central
    artinfo:
      ui:
        178402307
        178402307
        178402307
        10.1186/s12986-024-00822-y
        178402307
      ppf: 1
      ppct: 17
      formats:
        fmt:
          – @attributes:
              type: T
          – @attributes:
              type: P
      tig:
        atl: Dietary patterns and hepatocellular carcinoma risk: a systematic review and meta-analysis of cohort and case–control studies.
      aug:
        au:
          Shu, Wenxi
          Liu, Ling
          Jiang, Jiaojiao
          Yao, Qinghua
        affil: https://ror.org/04epb4p87 Second Clinical Medical College, Zhejiang Chinese Medical University, 310053, Hangzhou, China
      sug:
        subj:
          Carcinoma, Hepatocellular Risk Factors
          Dietary Patterns
          Risk Assessment
          Human
          Male
          Female
          Adult
          Middle Age
          Aged
          Systematic Review
          Meta Analysis
          Prospective Studies
          Case Control Studies
          PubMed
          Embase
          Cochrane Library
          Checklists
          Confidence Intervals
          Mediterranean Diet
          Vegetarianism
          Relative Risk
          Odds Ratio
          Statistical Significance
          Data Analysis Software
          Descriptive Statistics
          Funding Source
          Adult: 19-44 years
          Middle Aged: 45-64 years
          Aged: 65+ years
          Male
          Female
      ab: Background: Globally, HCC presents a significant health burden, characterized by high incidence and mortality rates. Epidemiological studies have increasingly suggested a link between dietary patterns and the risk of hepatocellular carcinoma (HCC), yet consensus on this relationship remains elusive. Objective: This study aims to synthesize existing literature and provide a comprehensive analysis of the association between dietary patterns and HCC risk through meta-analytical methods. Methods: A systematic search of PubMed, Embase, and the Cochrane Library databases was conducted to identify studies examining common dietary patterns in relation to HCC, published up to August 2023. Study quality was rigorously evaluated using the Newcastle–Ottawa Scale. We employed a random effects model to synthesize effect sizes, calculating hazard ratios (HRs) and 95% confidence intervals (CIs). Results: We identified 13 papers, of these 10 investigating a priori dietary patterns(index-based dietary patterns) and 3 focusing on a posterior dietary patterns (data-driven dietary patterns). Analysis of a priori dietary patterns revealed that higher scores in the Healthy Eating Index (HEI) & alternative HEI (HR = 0.67, 95% CI: 0.54–0.85), Dietary Approaches to Stop Hypertension (DASH) (HR = 0.77, 95% CI: 0.66–0.91), and the Mediterranean diet (HR = 0.65, 95% CI: 0.56–0.75) were associated with a reduced risk of HCC. Conversely, pro-inflammatory dietary patterns were linked with an increased risk (HR = 2.21, 95% CI: 1.58–3.09). In a posterior dietary patterns, a vegetable-based diet was negatively correlated with HCC risk (HR = 0.63, 95% CI: 0.49–0.81). Conclusion: This meta-analysis underscores a significant association between dietary patterns and the risk of HCC. Adherence to healthy dietary patterns characterized by high in vegetables, whole grains, legumes, nuts, and low in red and processed meats may confer a protective effect against HCC, whereas inflammatory diets appear to elevate risk.
      pubtype: Academic Journal
      doctype:
        meta analysis
        research
        systematic review
        tables/charts
        Journal Article
      ougenre: Article
    language: English
    refInfo:
    holdings:
      @attributes:
        islocal: N