Exploring the neural and behavioral correlates of cognitive telerehabilitation in mild cognitive impairment with three distinct approaches.
Background: Currently, the impact of drug therapies on neurodegenerative conditions is limited. Therefore, there is a strong clinical interest in nonpharmacological interventions aimed at preserving functionality, delaying disease progression, reducing disability, and improving quality of life for b...
| Published in: | Frontiers in Aging Neuroscience pp. 1 - 11 |
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| Main Authors: | , , , , , , , , , , , |
| Format: | protocol tables/charts Journal Article |
| Published: |
Frontiers Media S.A.
2024
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| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=178406955&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 178406955 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 16634365 BG2U jtl: Frontiers in Aging Neuroscience issn: 16634365 maglogo: N pubinfo: dt: 2024 pid: 40038 pub: Frontiers Media S.A. artinfo: ui: 178406955 178406955 178406955 10.3389/fnagi.2024.1425784 178406955 ppf: 1 ppct: 10 formats: tig: atl: Exploring the neural and behavioral correlates of cognitive telerehabilitation in mild cognitive impairment with three distinct approaches. aug: au: Caminiti, Silvia Paola Bernini, Sara Bottiroli, Sara Mitolo, Micaela Manca, Riccardo Grillo, Valentina Avenali, Micol De Icco, Roberto Capellari, Sabina Carlesimo, Giovanni Augusto Venneri, Annalena Tassorelli, Cristina affil: Department of Brain and Behavioral Sciences, University of Pavia, Pavia, Italy. sug: subj: Cognition Disorders Rehabilitation Cognitive Therapy Telerehabilitation Neurodegenerative Diseases Rehabilitation Brain Physiology Functional Connectivity Randomized Controlled Trials Random Assignment Neuropsychological Tests Questionnaires Scales Magnetic Resonance Imaging Methods ab: Background: Currently, the impact of drug therapies on neurodegenerative conditions is limited. Therefore, there is a strong clinical interest in nonpharmacological interventions aimed at preserving functionality, delaying disease progression, reducing disability, and improving quality of life for both patients and their caregivers. This longitudinal multicenter Randomized Controlled Trial (RCT) applies three innovative cognitive telerehabilitation (TR) methods to evaluate their impact on brain functional connectivity reconfigurations and on the overall level of cognitive and everyday functions. Methods: We will include 110 participants with mild cognitive impairment (MCI). Fifty-five participants will be randomly assigned to the intervention group who will receive cognitive TR via three approaches, namely: (a) Network-based Cognitive Training (NBCT), (b) Home-based Cognitive Rehabilitation (HomeCoRe), or (c) Semantic Memory Rehabilitation Training (SMRT). The control group (n = 55) will receive an unstructured home-based cognitive stimulation. The rehabilitative program will last either 4 (NBTC) or 6 weeks (HomeCoRe and SMRT), and the control condition will be adapted to each TR intervention. The effects of TR will be tested in terms of Δ connectivity change, obtained from high-density electroencephalogram (HD-EEG) or functional magnetic resonance imaging at rest (rs-fMRI), acquired before (T0) and after (T1) the intervention. All participants will undergo a comprehensive neuropsychological assessment at four timepoints: baseline (T0), within 2 weeks (T1), and after 6 (T2) and 12 months (T3) from the end of TR. Discussion: The results of this RCT will identify a potential association between improvement in performance induced by individual cognitive TR approaches and modulation of resting-state brain connectivity. The knowledge gained with this study might foster the development of novel TR approaches underpinned by established neural mechanisms to be validated and implemented in clinical practice. pubtype: Academic Journal doctype: protocol tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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