Multilayer network analysis in patients with juvenile myoclonic epilepsy.
Introduction: We conducted a multilayer network analysis in patients with juvenile myoclonic epilepsy (JME) and healthy controls, to investigate the gray matter layer using a morphometric similarity network and analyze the white matter layer using structural connectivity. Methods: We enrolled 42 pat...
| Published in: | Neuroradiology Vol. 66; no. 8; pp. 1363 - 1372 |
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| Main Authors: | , , , |
| Format: | diagnostic images research tables/charts Journal Article |
| Published: |
Springer Nature
Aug2024
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| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=178416295&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 178416295 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00283940 NYZ jtl: Neuroradiology issn: 00283940 maglogo: N pubinfo: dt: Aug2024 vid: 66 iid: 8 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 178416295 177697303 178416295 178416295 10.1007/s00234-024-03390-3 178416295 ppf: 1363 ppct: 9 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Multilayer network analysis in patients with juvenile myoclonic epilepsy. aug: au: Lee, Dong Ah Lee, Won Hee Lee, Ho-Joon Park, Kang Min affil: https://ror.org/04xqwq985 Department of Neurology, Haeundae Paik Hospital, Inje University College of Medicine, Haeundae-ro 875, Haeundae-gu, 48108, Busan, Republic of Korea sug: subj: Epilepsy, Juvenile Myoclonic Gray Matter White Matter Human Magnetic Resonance Imaging Methods Female Male Adolescence Adult Adolescent: 13-18 years Adult: 19-44 years Female Male ab: Introduction: We conducted a multilayer network analysis in patients with juvenile myoclonic epilepsy (JME) and healthy controls, to investigate the gray matter layer using a morphometric similarity network and analyze the white matter layer using structural connectivity. Methods: We enrolled 42 patients with newly diagnosed JME and 53 healthy controls. Brain magnetic resonance imaging (MRI) using a three-tesla MRI scanner, including T1-weighted imaging and diffusion tensor imaging (DTI) were performed. We created a gray matter layer matrix with a morphometric similarity network using T1-weighted imaging, and a white matter layer matrix with structural connectivity using the DTI. Subsequently, we performed a multilayer network analysis by applying graph theory. Results: There were significant differences in network at the global level in the multilayer network analysis between the groups. The average multiplex participation of patients with JME was lower than that of healthy controls (0.858 vs. 0.878, p = 0.007). In addition, several regions showed significant differences in multiplex participation at the nodal level in the multilayer network analysis. Multiplex participation in the right entorhinal cortex was lower, whereas multiplex participation in the right supramarginal gyrus was higher at the nodal level in the multilayer network analysis of patients with JME compared to healthy controls. Conclusion: We demonstrated differences in network at the global and nodal levels in the multilayer network analysis between patients with JME and healthy controls. These features may be associated with the pathophysiology of JME and could help us understand the complex brain network in patients with JME. pubtype: Academic Journal doctype: diagnostic images research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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