A comprehensive evaluation of imaging features in pediatric spinal gliomas and their value in predicting tumor grade and histology.
Purpose: Pediatric spinal cord gliomas (PSGs) are rare in children and few reports detail their imaging features. We tested the association of tumoral grade with imaging features and proposed a novel approach to categorize post-contrast enhancement patterns in PSGs. Methods: This single-center, retr...
| Publicado en: | Neuroradiology Vol. 66; no. 8; pp. 1311 - 1325 |
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| Autores principales: | , , , , , |
| Formato: | diagnostic images research tables/charts Journal Article |
| Publicado: |
Springer Nature
Aug2024
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=178416297&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 178416297 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00283940 NYZ jtl: Neuroradiology issn: 00283940 maglogo: N pubinfo: dt: Aug2024 vid: 66 iid: 8 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 178416297 177981598 178416297 178416297 10.1007/s00234-024-03395-y 178416297 ppf: 1311 ppct: 14 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: A comprehensive evaluation of imaging features in pediatric spinal gliomas and their value in predicting tumor grade and histology. aug: au: Cerron-Vela, Carmen Rosa Gonçalves, Fabrício Guimarães Tierradentro-García, Luis Octavio Viaene, Angela N Lerebo, Wondwossen Andronikou, Savvas affil: Department of Radiology, Children's Hospital of Philadelphia, University of Pennsylvania, Philadelphia, PA, USA sug: subj: Spinal Cord Neoplasms Diagnosis Glioma Diagnosis Neoplasm Staging Histology Magnetic Resonance Imaging Evaluation Childhood Neoplasms Human Child Adolescence Male Female Retrospective Design Record Review Spinal Cord Neoplasms Pathology Radiologists Fisher's Exact Test Descriptive Statistics Syringomyelia Contrast Media Child: 6-12 years Adolescent: 13-18 years Male Female ab: Purpose: Pediatric spinal cord gliomas (PSGs) are rare in children and few reports detail their imaging features. We tested the association of tumoral grade with imaging features and proposed a novel approach to categorize post-contrast enhancement patterns in PSGs. Methods: This single-center, retrospective study included patients <21 years of age with preoperative spinal MRI and confirmed pathological diagnosis of PSG from 2000-2022. Tumors were classified using the 5th edition of the WHO CNS Tumors Classification. Two radiologists reviewed multiple imaging features, and classified enhancement patterns using a novel approach. Fisher's exact test determined associations between imaging and histological features. Results: Forty-one PSGs were reviewed. Thirty-four were intramedullary, and seven were extramedullary. Pilocytic astrocytoma was the most common tumor (39.02%). Pain and weakness were the most prevalent symptoms. Seven patients (17.07%) died. Cyst, syringomyelia, and leptomeningeal enhancement were associated with tumor grade. Widening of the spinal canal was observed only in low-grade astrocytomas. There was a significant association between tumor grade and contrast enhancement pattern. Specifically, low-grade PSGs were more likely to exhibit type 1A enhancement (mass-like, with well-defined enhancing margins) and less likely to exhibit type 1B enhancement (mass-like, with ill-defined enhancing margins). Conclusion: PSGs display overlapping imaging features, making grade differentiation challenging based solely on imaging. The correlation between tumor grade and contrast enhancement patterns suggests a potential diagnostic avenue, requiring further validation with larger, multicenter studies. Furthermore, Low-grade PSGs display cysts and syringomyelia more frequently, and leptomeningeal enhancement is less common. pubtype: Academic Journal doctype: diagnostic images research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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