Mapping macrostructural and microstructural brain alterations in patients with neuronal intranuclear inclusion disease.
Background and purpose: Neuronal intranuclear inclusion disease (NIID) is a rare complex neurodegenerative disorder presents with various radiological features. The study aimed to investigate the structural abnormalities in NIID using multi-shell diffusion MR. Materials and methods: Twenty-eight pat...
| Publicado en: | Neuroradiology Vol. 66; no. 8; pp. 1373 - 1383 |
|---|---|
| Autores principales: | , , , , , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Springer Nature
Aug2024
|
| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=178416302&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 178416302 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00283940 NYZ jtl: Neuroradiology issn: 00283940 maglogo: N pubinfo: dt: Aug2024 vid: 66 iid: 8 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 178416302 177813235 178416302 178416302 10.1007/s00234-024-03406-y 178416302 ppf: 1373 ppct: 10 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Mapping macrostructural and microstructural brain alterations in patients with neuronal intranuclear inclusion disease. aug: au: Lv, Shan Tai, Hongfei Sun, Jun Zhuo, Zhizheng Duan, Yunyun Liu, Shaocheng Wang, An Zhang, Zaiqiang Liu, Yaou affil: https://ror.org/013xs5b60 Department of Radiology, Beijing Tiantan Hospital, Capital Medical University, 100070, Beijing, China sug: subj: Neurodegenerative Diseases Pathology Magnetic Resonance Imaging Methods Neurodegenerative Diseases Radiography Brain Pathology Diagnostic Imaging Human Male Female Adult Middle Age Aged Questionnaires Case Control Studies Cognition Disorders Adult: 19-44 years Middle Aged: 45-64 years Aged: 65+ years Male Female ab: Background and purpose: Neuronal intranuclear inclusion disease (NIID) is a rare complex neurodegenerative disorder presents with various radiological features. The study aimed to investigate the structural abnormalities in NIID using multi-shell diffusion MR. Materials and methods: Twenty-eight patients with adult-onset NIID and 32 healthy controls were included. Volumetric and diffusion MRI measures, including volume, fractional anisotropy (FA), mean diffusivity (MD), intracellular volume fraction (ICVF), orientation dispersion index (ODI), and isotropic volume fraction (ISOVF) of six brain structures, including cortex, subcortical GM, cerebral WM, cerebellar GM and WM, and brainstem, were obtained and compared between NIID and healthy controls. Associations between MRI measures and clinical variables were investigated. Results: Brain lesions of NIID included corticomedullary junction lesions on DWI, confluent leukoencephalopathy, lesions on callosum, cerebellar middle peduncle, cerebellar paravermal area and brainstem, and brain atrophy. Compared to healthy controls, NIID showed extensive volume loss of all the six brain regions (all p < 0.001); lower FA in cerebral WM (p < 0.001); higher MD in all WM regions; lower ODI in cortex (p < 0.001); higher ODI in subcortical GM (p < 0.001) and brainstem (p = 0.016); lower ICVF in brainstem (p = 0.001), and cerebral WM (p < 0.001); higher ISOVF in all the brain regions (p < 0.001). Higher MD of cerebellar WM was associated with worse cognitive level as evaluated by MoCA scores (p = 0.011). Conclusions: NIID patients demonstrated widespread brain atrophy but heterogeneous diffusion alterations. Cerebellar WM integrity impairment was correlated with the cognitive decline. The findings of the current study offer a sophisticated picture of brain structural alterations in NIID. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
|---|