The Impact of Specific Physical Training on FGF-2 and VEGF-A Expression in Patients Post-Coronary Artery Bypass Surgery.
Introduction: Coronary artery bypass surgery (CABG) is a common procedure for patients with coronary artery disease. This study aimed to investigate the effect of selected physical exercises on the expression of FGF-2 and VEGF-A in patients post-CABG. Material & Methods: In this semi-experimental st...
| Publicado en: | Journal of Basic Research in Medical Sciences Vol. 11; no. 3; pp. 56 - 66 |
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| Autores principales: | , , |
| Formato: | research tables/charts randomized controlled trial Journal Article |
| Publicado: |
Ilam University of Medical Sciences
2024
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=178436531&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 178436531 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 23830506 N1MR jtl: Journal of Basic Research in Medical Sciences issn: 23830506 maglogo: N pubinfo: dt: 2024 vid: 11 iid: 3 pid: 63388 pub: Ilam University of Medical Sciences artinfo: ui: 178436531 178436531 178436531 178436531 ppf: 56 ppct: 10 formats: fmt: @attributes: type: P tig: atl: The Impact of Specific Physical Training on FGF-2 and VEGF-A Expression in Patients Post-Coronary Artery Bypass Surgery. aug: au: Monjezi, Maryam Barari, Alireza Abdi, Ahmad affil: Department of Sport Physiology, Ayatollah Amoli Branch, Islamic Azad University, Amol, Iran sug: subj: Fibroblast Growth Factors Metabolism Vascular Endothelial Growth Factor A Metabolism Gene Expression Physical Activity Coronary Artery Bypass Surgical Patients Training Effect (Physiology) Human Randomized Controlled Trials Random Assignment Pretest-Posttest Design Iran Endurance Training Resistance Training Upper Extremity Exercises Lower Extremity Exercises Exercise Intensity Male Reverse Transcriptase Polymerase Chain Reaction Descriptive Statistics One-Way Analysis of Variance T-Tests Data Analysis Software Interviews Protocols Middle Age Aged Body Mass Index Heart Rate Systolic Pressure Diastolic Pressure Adaptation, Physiological Middle Aged: 45-64 years Aged: 65+ years Male ab: Introduction: Coronary artery bypass surgery (CABG) is a common procedure for patients with coronary artery disease. This study aimed to investigate the effect of selected physical exercises on the expression of FGF-2 and VEGF-A in patients post-CABG. Material & Methods: In this semi-experimental study, 20 male patients from Afshar Hospital (Yazd City) who had undergone CABG were selected and randomly divided into two groups: a combined training group and a control group. The combined training group performed an 8-week program consisting of endurance training (15-20 minutes at 50-60% of HRmax) and resistance training (10-20 minutes, including three upper limb and two lower limb movements, each with three sets of 10 repetitions at 3060% of 1RM), conducted three times per week. Gene expression of Fibroblast Growth Factor 2 (FGF-2) and Vascular Endothelial Growth Factor A (VEGF-A) was measured using Real-Time PCR. Data were analyzed using paired t-tests and one-way ANOVA with a significance level set at P<0.05. Results: An increase in the expression of VEGF and FGF-2 genes was observed in the combined training group post-test compared to pre-test (p=0.019). Additionally, there was a significant difference in VEGF gene expression between the control and training groups (p=0.016). Significant differences were also found in FGF-2 expression between the combined exercise group and both the healthy control and patient control groups (p=0.001 for both). Conclusion: The results suggest that combined exercises may enhance physiological adaptations and improve the functional capacity of the heart and vessels in CABG patients by increasing growth factor expression. pubtype: Academic Journal doctype: research tables/charts randomized controlled trial Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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