Fungal Microbiota Composition in Inflammatory Bowel Disease Patients: Characterization in Different Phenotypes and Correlation With Clinical Activity and Disease Course.
Background There is growing evidence of the role of the mycobiome in inflammatory bowel disease (IBD). Variations within phenotypes and activity and with prognosis have been poorly studied. Methods A total of 111 individuals were prospectively enrolled: 89 IBD patients (52 ulcerative colitis and 37...
| Published in: | Inflammatory Bowel Diseases Vol. 30; no. 7; pp. 1164 - 1178 |
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| Main Authors: | , , , , , , |
| Format: | research tables/charts Journal Article |
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Oxford University Press / USA
Jul2024
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| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=178481334&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 178481334 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 10780998 N0V jtl: Inflammatory Bowel Diseases issn: 10780998 maglogo: N pubinfo: dt: Jul2024 vid: 30 iid: 7 pid: 622 pub: Oxford University Press / USA artinfo: ui: 178481334 178481334 178481334 10.1093/ibd/izad289 178481334 ppf: 1164 ppct: 14 formats: tig: atl: Fungal Microbiota Composition in Inflammatory Bowel Disease Patients: Characterization in Different Phenotypes and Correlation With Clinical Activity and Disease Course. aug: au: Catalán-Serra, Ignacio Thorsvik, Silje Beisvag, Vidar Bruland, Torunn Underhill, David Sandvik, Arne Kristian Granlund, Atle van Beelen affil: Centre of Molecular Inflammation Research, NTNU-Norwegian University of Science and Technology , Trondheim , Norway sug: subj: Inflammatory Bowel Diseases Microbiology Disease Attributes Disease Progression Fungi Gut Microbiota Phenotype Human Correlational Studies Prospective Studies Colitis, Ulcerative Microbiology Crohn Disease Microbiology Feces Candida Albicans Aspergillus Health Status Descriptive Statistics Saccharomyces Neutrophils Cryptococcus Data Analysis Software ab: Background There is growing evidence of the role of the mycobiome in inflammatory bowel disease (IBD). Variations within phenotypes and activity and with prognosis have been poorly studied. Methods A total of 111 individuals were prospectively enrolled: 89 IBD patients (52 ulcerative colitis and 37 Crohn's disease [CD]) and 22 healthy individuals. Disease characteristics were collected and a fecal calprotectin >100 μg/mg was considered indicative of activity. A subset of patients was followed for 6 ± 2 years. Disease course was designated as either complicated or uncomplicated based on the need of intensified medication and/or surgery. ITS sequencing was performed targeting the ITS1 region. Results We found lower Ascomycota/Basidiomycota ratio in IBD. Patients showed a marked increase in Candida dublinensis and Ca albicans and were depleted of Aspergillus rubrobrunneus and Penicillium brevicompactum (P ≤.001) Saccharomyces was predominant in total colitis and Penicillium in proctitis. Several Penicillium species were depleted in total colitis vs proctitis. Ileal CD patients were enriched in Debaromyces hansenii and depleted of Ca tropicalis (P ≤.001). Ca albicans was overrepresented in inflammatory (B1) vs fibrostenosing (B2) CD. Ca dublinensis was more abundant in active patients and correlated positively with fecal calprotectin and neutrophil gelatinase-associated lipocalin, while S pastorianus correlated inversely with activity. Ca sake was associated with complicated disease and increased abundance of Cryptococcus carnescens with the need for surgery in CD. Conclusions This study shows important differences in the mycobiome in IBD and within phenotypes. Selected fungal species were associated with complicated disease and the need of surgery in CD. This work adds to our understanding of the role of fungi in IBD, with potential clinical implications. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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