Shared atypical spontaneous brain activity pattern in early onset schizophrenia and autism spectrum disorders: evidence from cortical surface-based analysis.
Schizophrenia and autism spectrum disorders (ASD) were considered as two neurodevelopmental disorders and had shared clinical features. we hypothesized that they have some common atypical brain functions and the purpose of this study was to explored the shared brain spontaneous activity strength alt...
| Publicado en: | European Child & Adolescent Psychiatry Vol. 33; no. 7; pp. 2387 - 2397 |
|---|---|
| Autores principales: | , , , , , , , , , , |
| Formato: | diagnostic images research tables/charts Journal Article |
| Publicado: |
Springer Nature
Jul2024
|
| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=178483448&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 178483448 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 10188827 EJ3 jtl: European Child & Adolescent Psychiatry issn: 10188827 maglogo: N pubinfo: dt: Jul2024 vid: 33 iid: 7 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 178483448 174436143 178483448 178483448 10.1007/s00787-023-02333-2 178483448 ppf: 2387 ppct: 10 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Shared atypical spontaneous brain activity pattern in early onset schizophrenia and autism spectrum disorders: evidence from cortical surface-based analysis. aug: au: Jin, Xingyue Zhang, Kun Lu, Bin Li, Xue Yan, Chao-Gan Du, Yasong Liu, Yi Lu, Jianping Luo, Xuerong Gao, Xueping Liu, Jing affil: https://ror.org/053v2gh09 Department of Psychiatry, National Clinical Research Center for Mental Disorders, and National Center for Mental Disorders, The Second Xiangya Hospital of Central South University, 410011, Changsha, Hunan, China sug: subj: Autism Spectrum Disorder In Infancy and Childhood Schizophrenia In Infancy and Childhood Brain Physiology Brain Radiography Autism Spectrum Disorder In Adolescence Schizophrenia In Adolescence Human Male Female Child Adolescence Multicenter Studies Magnetic Resonance Imaging Descriptive Statistics Funding Source Child: 6-12 years Adolescent: 13-18 years Male Female ab: Schizophrenia and autism spectrum disorders (ASD) were considered as two neurodevelopmental disorders and had shared clinical features. we hypothesized that they have some common atypical brain functions and the purpose of this study was to explored the shared brain spontaneous activity strength alterations in early onset schizophrenia (EOS) and ASD in the children and adolescents with a multi-center large-sample study. A total of 171 EOS patients (aged 14.25 ± 1.87), 188 ASD patients (aged 9.52 ± 5.13), and 107 healthy controls (aged 11.52 ± 2.82) had scanned with Resting-fMRI and analyzed surface-based amplitude of low-frequency fluctuations (ALFF). Results showed that both EOS and ASD had hypoactivity in the primary sensorimotor regions (bilateral primary and early visual cortex, left ventral visual stream, left primary auditory cortex) and hyperactivity in the high-order transmodal regions (bilateral SFL, bilateral DLPFC, right frontal eye fields), and bilateral thalamus. EOS had more severe abnormality than ASD. This study revealed shared functional abnormalities in the primary sensorimotor regions and the high-order transmodal regions in EOS and ASD, which provided neuroimaging evidence of common changes in EOS and ASD, and may help with better early recognition and precise treatment for EOS and ASD. pubtype: Academic Journal doctype: diagnostic images research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
|---|