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Research and development of microenvironment’s influence on stem cells from the apical papilla – construction of novel research microdevices: tooth-on-a-chip.

Stem cells are crucial in tissue engineering, and their microenvironment greatly influences their behavior. Among the various dental stem cell types, stem cells from the apical papilla (SCAPs) have shown great potential for regenerating the pulp–dentin complex. Microenvironmental cues that affect SC...

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Published in:Biomedical Microdevices Vol. 26; no. 3; pp. 1 - 18
Main Authors: Zhang, Hexuan, Li, Lingjun, Sun, Xiaoqiang, Hou, Benxiang, Luo, Chunxiong
Format: Journal Article
Published: Springer Nature Sep2024
Online Access:View this record in EBSCOhost
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      dt: Sep2024
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      pub: Springer Nature
      place: New York, New York
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        10.1007/s10544-024-00715-0
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        atl: Research and development of microenvironment’s influence on stem cells from the apical papilla – construction of novel research microdevices: tooth-on-a-chip.
      aug:
        au:
          Zhang, Hexuan
          Li, Lingjun
          Sun, Xiaoqiang
          Hou, Benxiang
          Luo, Chunxiong
        affil: https://ror.org/013xs5b60 Center for Microscope Enhanced Dentistry, School of Stomatology, Capital Medical University, Beijing, China
      sug:
      ab: Stem cells are crucial in tissue engineering, and their microenvironment greatly influences their behavior. Among the various dental stem cell types, stem cells from the apical papilla (SCAPs) have shown great potential for regenerating the pulp–dentin complex. Microenvironmental cues that affect SCAPs include physical and biochemical factors. To research optimal pulp–dentin complex regeneration, researchers have developed several models of controlled biomimetic microenvironments, ranging from in vivo animal models to in vitro models, including two-dimensional cultures and three-dimensional devices. Among these models, the most powerful tool is a microfluidic microdevice, a tooth-on-a-chip with high spatial resolution of microstructures and precise microenvironment control. In this review, we start with the SCAP microenvironment in the regeneration of pulp–dentin complexes and discuss research models and studies related to the biological process.
      pubtype: Academic Journal
      doctype: Journal Article
      ougenre: Article
    language: English
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