The variations of selected serum cytokines involved in cytokine Storm after Omega-3 daily supplements: A Randomized Clinical Trial in Jordanians with vitamin D deficiency.
The aim of this study was to investigate the effects of supplementing unsaturated free fatty acids (n-3FA) on the levels of specific cytokines associated with cytokine storm in the blood of 72 Jordanian individuals (both men and women) who had insufficient vitamin D. The study was conducted using a...
| Publicado en: | Pharmacy Practice (1886-3655) Vol. 22; no. 2; pp. 1 - 11 |
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| Autores principales: | , , , , , , , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Centro de Investigaciones y Publicaciones Farmaceuticas S.L.
Apr-Jun2024
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=178612446&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 178612446 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 1885642X 3EAU jtl: Pharmacy Practice (1886-3655) issn: 1885642X maglogo: N pubinfo: dt: Apr-Jun2024 vid: 22 iid: 2 pid: 36266 pub: Centro de Investigaciones y Publicaciones Farmaceuticas S.L. artinfo: ui: 178612446 178612446 178612446 10.18549/PharmPract.2024.2.2951 178612446 ppf: 1 ppct: 10 formats: fmt: @attributes: type: P tig: atl: The variations of selected serum cytokines involved in cytokine Storm after Omega-3 daily supplements: A Randomized Clinical Trial in Jordanians with vitamin D deficiency. aug: au: AL Khaled, Rafeef Alhmoud, Jehad F. Issa, Reem Khader, Heba A. Mohammad, Beisan A. Alsayed, Ahmad R. Khadra, Khalid Abu Habash, Maha Aljaberi, Ahmad Hasoun, Luai Abu-Samak, Mahmoud S. affil: Department of Clinical Pharmacy and Therapeutics, Applied Science Private University, Amman 11931, Jordan sug: subj: Cytokine Release Syndrome Fatty Acids, omega-3 Dietary Supplements Cytokines Blood Vitamin D Deficiency Drug Therapy Human Male Female Jordan Randomized Controlled Trials Random Assignment Tumor Necrosis Factor Blood Lipids Blood Blood Glucose Preprocedural Fasting Interleukins Blood Comparative Studies Male Female ab: The aim of this study was to investigate the effects of supplementing unsaturated free fatty acids (n-3FA) on the levels of specific cytokines associated with cytokine storm in the blood of 72 Jordanian individuals (both men and women) who had insufficient vitamin D. The study was conducted using a randomized controlled design (RCT). Individuals eligible for the study were randomly assigned to either the n-3FA supplemented (intervention) group or the non-supplemented (control) group. The intervention group received 1,000 mg of wild salmon and fish oil complex, which is equivalent to 300 mg of n-3FA, for a duration of eight weeks, while the control group did not. Blood tests to assess tumor necrosis factor-α (TNF-α), lipid profile, and fasting blood sugar were conducted at baseline and after ten weeks (with a two-week washout period). Additionally, interleukin-6 (IL-6), interleukin-1β (IL-1β), and interleukin-10 (IL-10) levels were measured. Our research indicates that taking n-3FA supplements significantly raised IL-1 β, IL-6, and IL-10 levels compared to their initial levels. However, TNF-α levels did not show any significant changes. The interesting results of this randomized controlled trial could be due to a possible harmful effect of n-3FA supplementation during cytokine storms (CS), specifically on IL-6. Therefore, additional clinical studies are needed in the target patients during cytokine storm to determine if this supplement could affect the treatment with IL-6 antagonists.. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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