Effect of weekly high-dose vitamin D3 supplementation on the association between circulatory FGF-23 and A1c levels in people with vitamin D deficiency: A randomized controlled 10-week follow-up trial.
Purpose: This randomized clinical trial (RCT) was designed to assess the effect of vitamin D supplementation (VD3) on the relationship between the levels of fibroblast growth factor-23 (FGF-23) and osteocalcin factor (OSC) with glycated hemoglobin (A1c) values in the blood in a sample of Jordanian m...
| Publicado en: | Pharmacy Practice (1886-3655) Vol. 22; no. 2; pp. 1 - 9 |
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| Autores principales: | , , , , , , , , , , , |
| Formato: | research tables/charts randomized controlled trial Journal Article |
| Publicado: |
Centro de Investigaciones y Publicaciones Farmaceuticas S.L.
Apr-Jun2024
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=178612455&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 178612455 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 1885642X 3EAU jtl: Pharmacy Practice (1886-3655) issn: 1885642X maglogo: N pubinfo: dt: Apr-Jun2024 vid: 22 iid: 2 pid: 36266 pub: Centro de Investigaciones y Publicaciones Farmaceuticas S.L. artinfo: ui: 178612455 178612455 178612455 10.18549/PharmPract.2024.2.2934 178612455 ppf: 1 ppct: 8 formats: fmt: @attributes: type: P tig: atl: Effect of weekly high-dose vitamin D3 supplementation on the association between circulatory FGF-23 and A1c levels in people with vitamin D deficiency: A randomized controlled 10-week follow-up trial. aug: au: Alimam, Sara M. Alhmoud, Jehad F. Khader, Heba A. Alsayed, Ahmad R. Abusamak, Mohammad Mohammad, Beisan A. Mosleh, Ibrahim Khadrah, Khaled Abu Aljaberi, Ahmad Habash, Maha Hasoun, Luai Abu-Samak, Mahmoud S. affil: Department of Clinical Pharmacy and Therapeutics, Applied Science Private University, Amman 11931, Jordan sug: subj: Cholecalciferol Administration and Dosage Dietary Supplementation Fibroblast Growth Factor-23 Drug Effects Hemoglobin A Drug Effects Osteocalcin Drug Effects Vitamin D Deficiency Treatment Outcomes Cholecalciferol Pharmacodynamics Human Randomized Controlled Trials Random Assignment Jordan Male Female Parathyroid Hormones Drug Effects Calcium Drug Effects Phosphorus Drug Effects Descriptive Statistics Paired T-Tests Adult Glycemic Control Adult: 19-44 years Male Female ab: Purpose: This randomized clinical trial (RCT) was designed to assess the effect of vitamin D supplementation (VD3) on the relationship between the levels of fibroblast growth factor-23 (FGF-23) and osteocalcin factor (OSC) with glycated hemoglobin (A1c) values in the blood in a sample of Jordanian males and female adults with vitamin D deficiency. Subjects and methods: This RCT was designed to randomly split (78) eligible participants into two groups: experimental (Group A) and interventional (Group B). Group B was supplemented with a weekly dose of 50,000 IU VD3 for eight weeks. Fasting baseline and follow-up (10 weeks; 8 weeks supplementation plus washout two weeks) of serum 25 hydroxyvitamin D (25OHD), fibroblast growth factor-23, (FGF- 23), glycosylated hemoglobin (A1c), parathyroid hormone (PTH), calcium, and phosphorus were assayed. A paired T-test was used to assess the changes in fibroblast growth factor-23, A1c, and OSC levels over the follow-up period. RESULTS: Significant increase in follow-up level of 25OHD (40.04 ± 11.61 vs. 15.35 ± 5.41, PC < 0.001), FGF-23 (114.04 ± 103.8 vs. 87.40 ± 82.21, PA = 0.02) and A1c (5.63 ± 0.33 vs. 5.38 ± 0.32, PA = 0.01). Conclusion: High doses of vitamin D supplementation (50,000 IU/week) may have potentially negative effects on glycemic control, which might be related to changes in serum osteocalcin than in FGF23 levels. pubtype: Academic Journal doctype: research tables/charts randomized controlled trial Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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