Gray matter asymmetry alterations in children and adolescents with comorbid autism spectrum disorder and attention-deficit/hyperactivity disorder.
Despite the high coexistence of autism spectrum disorder (ASD) and attention-deficit/hyperactivity disorder (ADHD) (ASD + ADHD), the underlying neurobiological basis of this disorder remains unclear. Altered brain structural asymmetries have been verified in ASD and ADHD, respectively, making brain...
| Published in: | European Child & Adolescent Psychiatry Vol. 33; no. 8; pp. 2593 - 2605 |
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| Main Authors: | , , , , , , , , |
| Format: | diagnostic images research tables/charts Journal Article |
| Published: |
Springer Nature
Aug2024
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| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=178622999&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 178622999 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 10188827 EJ3 jtl: European Child & Adolescent Psychiatry issn: 10188827 maglogo: N pubinfo: dt: Aug2024 vid: 33 iid: 8 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 178622999 174491019 178622999 178622999 10.1007/s00787-023-02323-4 178622999 ppf: 2593 ppct: 12 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Gray matter asymmetry alterations in children and adolescents with comorbid autism spectrum disorder and attention-deficit/hyperactivity disorder. aug: au: Li, Cuicui Zhang, Rui Zhou, Yunna Li, Tong Qin, Rui Li, Lin Yuan, Xianshun Wang, Li Wang, Ximing affil: Department of Radiology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, No. 324, Jingwu Road, 250021, Jinan, Shandong, China sug: subj: Autism Spectrum Disorder Pathology Attention Deficit Hyperactivity Disorder Pathology Comorbidity Gray Matter Anatomy and Histology Gray Matter Physiology Human Male Female Child Adolescence Academic Medical Centers Gray Matter Radiography Magnetic Resonance Imaging Methods T-Tests Statistical Significance Data Analysis Software Descriptive Statistics Funding Source Child: 6-12 years Adolescent: 13-18 years Male Female ab: Despite the high coexistence of autism spectrum disorder (ASD) and attention-deficit/hyperactivity disorder (ADHD) (ASD + ADHD), the underlying neurobiological basis of this disorder remains unclear. Altered brain structural asymmetries have been verified in ASD and ADHD, respectively, making brain asymmetry a candidate for characterizing this coexisting disorder. Here, we measured the gray matter (GM) volume asymmetry in ASD + ADHD versus ASD without ADHD (ASD-only), ADHD without ASD (ADHD-only), and typically developing controls (TDc). High-resolution T1-weighted data from 48 ASD + ADHD, 63 ASD-only, 32 ADHD-only, and 211 matched TDc were included in our study. We also assessed brain-behavior relationships and the effects of age on GM asymmetry. We found that there were both shared and disorder-specific GM volume asymmetry alterations in ASD + ADHD, ASD-only, and ADHD-only compared with TDc. This finding demonstrates that ASD + ADHD is neither an endophenocopy nor an additive pathology of ASD and ADHD, but an entirely different neuroanatomical pathology. In addition, ASD + ADHD displayed altered GM volume asymmetries in the prefrontal regions responsible for executive function and theory of mind compared with ASD-only. We also found significant effects of age on GM asymmetry. The present study may provide structural insights into the neural basis of ASD + ADHD. pubtype: Academic Journal doctype: diagnostic images research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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