Associations of 10-year atherosclerotic cardiovascular disease risk scores with cerebral small vessel disease: the PolyvasculaR Evaluation for Cognitive Impairment and vaScular Events (PRECISE) study.
Background 10-year atherosclerotic cardiovascular disease (ASCVD) risk scores were useful for predicting large vessel disease, but the relationships between them and cerebral small vessel disease (CSVD) were unclear. Our study aimed to evaluate associations of 10-year ASCVD risk scores with CSVD and...
| Publicado en: | Age & Ageing Vol. 53; no. 7; pp. 1 - 12 |
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| Autores principales: | , , , , , , , , , , , , , |
| Formato: | Artículo |
| Publicado: |
Oxford University Press / USA
Jul2024
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| Materias: | |
| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ssf&AN=178718773&site=ehost-live header: @attributes: shortDbName: ssf uiTerm: 178718773 longDbName: Social Sciences Full Text (H.W. Wilson) uiTag: AN controlInfo: bkinfo: jinfo: jid: 00020729 AGA jtl: Age & Ageing issn: 00020729 maglogo: N pubinfo: dt: Jul2024 vid: 53 iid: 7 pid: 622 pub: Oxford University Press / USA artinfo: ui: 178718773 10.1093/ageing/afae161 ppf: 1 ppct: 11 formats: tig: atl: Associations of 10-year atherosclerotic cardiovascular disease risk scores with cerebral small vessel disease: the PolyvasculaR Evaluation for Cognitive Impairment and vaScular Events (PRECISE) study. aug: au: Liu, Dandan Zhang, Yanli Cai, Xueli Yang, Yingying Wang, Suying Mei, Lerong Jing, Jing Li, Shan Wang, Mengxing Meng, Xia Wei, Tiemin Wang, Yongjun Wang, Yilong Pan, Yuesong affil: Department of Neurology, Beijing Tiantan Hospital, Capital Medical University , Beijing, China China National Clinical Research Center for Neurological Diseases , Beijing, China Department of Clinical Epidemiology and Clinical Trial, Capital Medical University , Beijing, China Department of Neurology, The Fifth Affiliated Hospital of Wenzhou Medical University , Lishui, Zhejiang, China Lishui Clinical Research Center for Neurological Diseases , Lishui, Zhejiang, China Cerebrovascular Research Lab, The Fifth Affiliated Hospital of Wenzhou Medical University , Lishui, Zhejiang, China Department of Cardiology, The Fifth Affiliated Hospital of Wenzhou Medical University , Lishui, Zhejiang, China Chinese Institute for Brain Research , Beijing, China National Center for Neurological Diseases , Beijing, China Advanced Innovation Center for Human Brain Protection, Capital Medical University , Beijing, China su: China Cross-sectional method Stroke Disease risk factors Cognition disorders diagnosis Risk assessment Cardiovascular diseases Independent living Research funding Brain Magnetic resonance imaging Atherosclerosis Basal ganglia Descriptive statistics Cerebral small vessel diseases Cognition disorders White matter (Nerve tissue) Coronary artery disease Cerebral hemorrhage sug: subj: Cross-sectional method Stroke Disease risk factors China Diagnostic Imaging Centers Cognition disorders diagnosis Risk assessment Cardiovascular diseases Independent living Research funding Brain Magnetic resonance imaging Atherosclerosis Basal ganglia Descriptive statistics Cerebral small vessel diseases Cognition disorders White matter (Nerve tissue) Coronary artery disease Cerebral hemorrhage keyword: 10-year atherosclerotic cardiovascular disease risk scores cerebral small vessel disease magnetic resonance imaging (MRI) older people 10-year atherosclerotic cardiovascular disease risk scores cerebral small vessel disease magnetic resonance imaging (MRI) older people ab: Background 10-year atherosclerotic cardiovascular disease (ASCVD) risk scores were useful for predicting large vessel disease, but the relationships between them and cerebral small vessel disease (CSVD) were unclear. Our study aimed to evaluate associations of 10-year ASCVD risk scores with CSVD and its magnetic resonance imaging (MRI) markers. Methods Community-dwelling residents from the PolyvasculaR Evaluation for Cognitive Impairment and vaScular Events study were included in this cross-sectional study. At baseline, we collected data related to the Framingham Risk Score (FRS), pooled cohort equation (PCE), prediction for ASCVD risk in China (China-PAR) and Systematic COronary Risk Evaluation model 2 (SCORE2), and classified participants into low, moderate and high groups. Participants underwent brain MRI scans. We evaluated white matter hyperintensity (WMH), lacunes, cerebral microbleeds (CMBs) and enlarged perivascular spaces in basal ganglia (BG-EPVS) according to criteria of Wardlaw and Rothwell, and calculated total CSVD score and modified total CSVD score. Results A total of 3063 participants were included, and 53.5% of them were female. A higher FRS was associated with higher total CSVD score (moderate vs. low: cOR 1.89, 95% CI 1.53–2.34; high vs. low: cOR 3.23, 95%CI 2.62–3.97), and the PCE, China-PAR or SCORE2 score was positively related to total CSVD score (P < 0.05). Moreover, higher 10-year ASCVD scores were associated with higher odds of WMH (P < 0.05), lacunes (P < 0.05), CMBs (P < 0.05) and BG-EPVS (P < 0.05). Conclusions The 10-year ASCVD scores were positively associated with CSVD and its MRI markers. These scores provided a method of risk stratification in the population with CSVD. pubtype: Academic Journal doctype: Article src: R language: English refInfo: copyright: @attributes: flag: N holdings: @attributes: islocal: N |
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