Factors Precipitating Breakthrough Seizures in Childhood Epilepsy.

Background: Breakthrough seizures occur in 37% of epilepsy patients even though remission has been attained. Counseling on precipitating factors form an integral part of treatment along with anti-epileptic drugs (AEDs). Identification of precipitating factors may help in reducing unnecessary hospita...

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Publicado en:Journal of Pediatric Neurosciences Vol. 17; no. 3; pp. 225 - 231
Autores principales: Thandapani, Kanimozhi, Revathi, K., Kumar, T. Bharath
Formato: research tables/charts Journal Article
Publicado: Wolters Kluwer India Pvt Ltd Jul-Sep2022
Acceso en línea:Ver este registro en EBSCOhost
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      dt: Jul-Sep2022
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      pub: Wolters Kluwer India Pvt Ltd
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        10.4103/jpn.jpn_256_20
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        atl: Factors Precipitating Breakthrough Seizures in Childhood Epilepsy.
      aug:
        au:
          Thandapani, Kanimozhi
          Revathi, K.
          Kumar, T. Bharath
        affil: Department of Pediatrics, Sri Manakula Vinayagar Medical College and Hospital, Puducherry, India
      sug:
        subj:
          Epilepsy Complications
          Seizures Risk Factors
          Risk Assessment
          Human
          Male
          Female
          Child, Preschool
          Child
          Tertiary Health Care India
          Hospitals, Pediatric India
          India
          Retrospective Design
          Descriptive Statistics
          Comparative Studies
          Counseling
          Anticonvulsants Therapeutic Use
          Epilepsy Drug Therapy
          Child, Preschool: 2-5 years
          Child: 6-12 years
          Male
          Female
      ab: Background: Breakthrough seizures occur in 37% of epilepsy patients even though remission has been attained. Counseling on precipitating factors form an integral part of treatment along with anti-epileptic drugs (AEDs). Identification of precipitating factors may help in reducing unnecessary hospitalization and complications of breakthrough seizures. Materials and Methods: This retrospective study was conducted in a tertiary healthcare center in Puducherry. All children with epilepsy admitted with breakthrough seizures from January 2017 to December 2019 were included in the study. Those with neonatal seizures, diagnosis of either Neurocysticercosis or tuberculoma, cases without seizure free period of 6 months and case records without adequate details were excluded. Data regarding precipitating factors were collected from case records and analyzed using SPSS version 24.0 software. Results: Of the 80 children included in the study, mean age was 4.98 (±3.52) years and 56.3% were less than 5 years of age. In total, 90% (n = 72) of the participants had generalized epilepsy, of which 67 had generalized seizures, four had absence seizures and one had atonic seizures. Majority (85%) reported at least one possible precipitating factor for breakthrough seizures and common ones were fever (27.5%) and non-compliance to medication (26.25%). Most common reason for non-compliance was forgetting to take medication (38%). Also illiterate mothers and multiple AEDs had a significant association with non-compliance (P < 0.05). Conclusion: The results of our study stress the need on adequate counseling about possible precipitants and prescription on minimum AEDs whenever possible. Parents need to ensure strict adherence to AEDs and avoidance of trigger factors.
      pubtype: Academic Journal
      doctype:
        research
        tables/charts
        Journal Article
      ougenre: Article
    language: English
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