The prevalence of human papillomavirus in ocular surface squamous neoplasia in HIV positive and negative patients in a South African population.
Purpose: To assess the prevalence and subtypes of Human Papillomavirus (HPV) in Ocular Surface Squamous Neoplasia (OSSN) in Human Immunodeficiency Virus (HIV) positive and negative patients in South Africa. Basic procedures: This study was a single center retrospective cross-sectional study, conduct...
| Published in: | Infection Vol. 52; no. 4; pp. 1547 - 1553 |
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| Main Authors: | , , , , |
| Format: | research tables/charts Journal Article |
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Springer Nature
Aug2024
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| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=178774670&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 178774670 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 03008126 NXO jtl: Infection issn: 03008126 maglogo: N pubinfo: dt: Aug2024 vid: 52 iid: 4 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 178774670 177123908 178774670 178774670 10.1007/s15010-024-02289-8 178774670 ppf: 1547 ppct: 6 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: The prevalence of human papillomavirus in ocular surface squamous neoplasia in HIV positive and negative patients in a South African population. aug: au: Odendaal, Loren N. Andreae, Corinna Sanderson-November, Micheline Zaharie, Dan Smit, Derrick P. affil: Division of Ophthalmology, Faculty of Medicine and Health Sciences, Stellenbosch University, Room 5053, Clinical Building, Francie Van Zijl Drive, 7505, Parow Valley, South Africa sug: subj: Carcinoma, Squamous Cell Epidemiology Carcinoma, Squamous Cell Microbiology Human Papillomavirus Viruses HIV Infections Microbiology HIV Infections Epidemiology Papillomavirus Infections Epidemiology Papillomavirus Infections Microbiology Papillomavirus Infections Prevention and Control Eye Neoplasms Epidemiology Human Male Female Adult Middle Age Aged Hospitals Retrospective Design Cross Sectional Studies Funding Source South Africa Prevalence Papillomaviruses Eye Neoplasms Microbiology Genotype HIV-Positive Persons CD4 Lymphocyte Count Papillomavirus Vaccine Therapeutic Use Immunization Formaldehyde Paraffin Embedding Vertebrate Viruses Carcinogens Descriptive Statistics Comparative Studies Confidence Intervals Adult: 19-44 years Middle Aged: 45-64 years Aged: 65+ years Male Female ab: Purpose: To assess the prevalence and subtypes of Human Papillomavirus (HPV) in Ocular Surface Squamous Neoplasia (OSSN) in Human Immunodeficiency Virus (HIV) positive and negative patients in South Africa. Basic procedures: This study was a single center retrospective cross-sectional study, conducted at Tygerberg Hospital, Western Cape, South Africa. We assessed 63 histopathologically confirmed OSSN formalin-fixed paraffin-embedded (FFPE) tissue blocks from 2015–2023. The presence of HPV was determined using the Hybrispot Direct Flow Chip Kit. Corresponding clinical data was retrieved from the National Health Laboratory Service (NHLS) central data warehouse. Main findings: Of the confirmed OSSN samples, 66.7% tested positive for HPV (95% confidence interval [CI] 54–77.3%). Of the 42 HPV positive samples, 38 (90.5%) had one or more known genotypes detected and 4 had unknown genotypes. The most prevalent subtypes were HPV 11, 16 and 18 (found in 61.9%, 52.4% and 33.3% of HPV positive samples respectively). 88.9% of the lesions biopsied were from HIV positive patients, of whom 56.4% had a CD4 + count of < 200 cells/µL. A lower median CD4 + count was detected among HIV positive patients with invasive squamous cell carcinoma compared to those with moderate dysplasia (p < 0.0198). Conclusions: There is a high prevalence of HPV in OSSN in South Africa. Certain subtypes namely, 11, 16, 18, 31, 33 and 35 may be more carcinogenic. HIV with HPV co-infection may be linked as a causative factor in the development of OSSN. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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